Department of Gerontological Nursing/Wound Care Management, Division of Health Science and Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Faculty of Nursing, School of Health Sciences, Fujita Health University, Aichi, Japan.
Int Wound J. 2023 Apr;20(4):1168-1182. doi: 10.1111/iwj.13976. Epub 2022 Nov 11.
Persistent and blanchable redness (PBR) is not currently included in category I pressure injury (PI), which is defined as non-blanchable redness (NBR). However, PBR progresses to PI in a clinical setting. Therefore, it should be clinically managed as category I PI, and a method to distinctly identify PBR is needed. This study aimed to examine whether PI-related biomarkers can distinguish PRB from transient redness (TR) and NBR using skin blotting. TR, PBR, and NBR models were established by the different conditions of dorsal skin compression. Redness observation and skin blotting were performed, and the skin tissue samples were subjected to histological and molecular biological analyses. The vascular endothelial growth factor (Vegf) b, heat shock protein (Hsp) 90aa1, tumour necrosis factor, interleukin (Il) 1b, and Il6 messenger ribonucleic acid levels were significantly different between the three models. The VEGF-A, VEGF-B, IL-1β, and IL-6 protein levels were different between the three models. Although the results of skin blot examinations were inconsistent with those of the expression analysis of tissue, HSP90α and IL-1β are suggested to be potential markers to distinguish PBR from TR and NBR.
持续性且可压退的红斑（PBR）目前未被纳入 I 类压力性损伤（PI）的范畴，因为 I 类 PI 的定义为不可压退的红斑（NBR）。然而，PBR 在临床环境中会进展为 PI。因此，它应该被临床视为 I 类 PI 进行管理，并且需要一种方法来明确区分 PBR。本研究旨在通过皮肤印片检查，探讨 PI 相关生物标志物是否可以区分 PBR 与短暂性红斑（TR）和 NBR。通过背部皮肤不同的压迫条件建立了 TR、PBR 和 NBR 模型。对红斑进行观察和皮肤印片检查，并对皮肤组织样本进行组织学和分子生物学分析。三个模型之间血管内皮生长因子（VEGF）b、热休克蛋白（Hsp）90aa1、肿瘤坏死因子、白细胞介素（IL）1b 和 IL6 信使核糖核酸水平有显著差异。VEGF-A、VEGF-B、IL-1β 和 IL-6 蛋白水平在三个模型之间也存在差异。尽管皮肤印片检查的结果与组织表达分析不一致，但 HSP90α 和 IL-1β 被认为是区分 PBR 与 TR 和 NBR 的潜在标志物。
