Ogai K, Matsumoto M, Aoki M, Minematsu T, Kitamura K, Kobayashi M, Sanada H, Sugama J
Wellness Promotion Science Center, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa, 9200942, Japan.
Division of Health Science, Department of Clinical Nursing, Graduate School of Medicine, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa, 9200942, Japan.
Int J Cosmet Sci. 2016 Oct;38(5):462-9. doi: 10.1111/ics.12312. Epub 2016 Mar 18.
A state of chronic inflammation, characterized by an increased level of tumour necrosis factor-alpha (TNF-α), is often found in the obese population. The negative effects of elevated TNF-α are not limited to systemic metabolism. It also reportedly affects skin integrity. Recently, the relationship between obesity and skin fragility was reported; however, there has been little insight into how the level of TNF-α in the skin in situ is related to the severity of obesity. In this study, we aimed to measure the level of TNF-α on the skin and to find the relationship between obesity and the level of TNF-α detected on the skin.
We used a novel, non-invasive method called quantitative skin blotting. Fifty-nine healthy (but some were classified as being overweight or obese) Japanese males were enrolled as subjects. The levels of TNF-α detected on the abdominal and thigh skin along with the body composition were measured, followed by a correlation analysis.
Significant positive correlations were found between the levels of TNF-α detected on the skin and the severity of obesity such as body mass index (BMI), body fat weight and visceral fat rating.
We found that high levels of TNF-α were detected on the skin of Japanese obese males, which implied the higher TNF-α in the skin. The elevation of skin TNF-α may be one factor related to skin fragility that is often found in obese individuals.
慢性炎症状态，其特征为肿瘤坏死因子-α（TNF-α）水平升高，在肥胖人群中较为常见。TNF-α升高的负面影响不仅限于全身代谢。据报道，它还会影响皮肤完整性。最近，有报道称肥胖与皮肤脆弱性之间存在关联；然而，对于皮肤原位TNF-α水平与肥胖严重程度之间的关系，人们了解甚少。在本研究中，我们旨在测量皮肤TNF-α水平，并找出肥胖与皮肤检测到的TNF-α水平之间的关系。
我们使用了一种名为定量皮肤印迹的新型非侵入性方法。59名健康的（但有些人被归类为超重或肥胖）日本男性被招募为受试者。测量腹部和大腿皮肤检测到的TNF-α水平以及身体成分，随后进行相关性分析。
在皮肤检测到的TNF-α水平与肥胖严重程度（如体重指数（BMI）、体脂肪重量和内脏脂肪等级）之间发现了显著的正相关。
我们发现日本肥胖男性的皮肤检测到高水平的TNF-α，这意味着皮肤中TNF-α含量更高。皮肤TNF-α升高可能是肥胖个体中常见的皮肤脆弱性相关因素之一。
