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外泌体在远隔效应中肿瘤微环境中的作用机制（综述）。

Mechanism of exosomes in the tumor microenvironment in the abscopal effect (Review).

机构信息

Clinical Medical College, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Department of Blood Transfusion, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

出版信息

Int J Oncol. 2023 Jan;62(1). doi: 10.3892/ijo.2022.5450. Epub 2022 Nov 11.

DOI:10.3892/ijo.2022.5450
PMID:36367187
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9699724/
Abstract

Previously, the abscopal effect, which is an antitumor therapeutic effect on untreated tumor locations elsewhere in the body as a result of treatment of the targeted region, was rarely reported, and its mechanism remains unknown. Increasing evidence has shown that the immune system is implicated in the abscopal effect, and that combining immunotherapy and radiation can assist to improve its frequency. Understanding how different types of cells and cell‑derived exosomes cause the abscopal effect in the tumor microenvironment (TME) is crucial to increasing the clinical occurrence of the abscopal effect in the TME.

摘要

先前，远隔效应（一种由于靶向区域治疗而导致身体其他未治疗肿瘤部位产生抗肿瘤治疗效果的现象）很少被报道，其机制尚不清楚。越来越多的证据表明，免疫系统与远隔效应有关，免疫疗法与放疗相结合有助于提高其频率。了解不同类型的细胞和细胞衍生的外泌体如何在肿瘤微环境（TME）中引起远隔效应，对于增加 TME 中远隔效应的临床发生至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91de/9699724/3b8338be7093/IJO-62-1-05450-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91de/9699724/ad70647b2004/IJO-62-1-05450-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91de/9699724/b436b498a374/IJO-62-1-05450-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91de/9699724/0636efc4680e/IJO-62-1-05450-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91de/9699724/3b8338be7093/IJO-62-1-05450-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91de/9699724/ad70647b2004/IJO-62-1-05450-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91de/9699724/b436b498a374/IJO-62-1-05450-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91de/9699724/0636efc4680e/IJO-62-1-05450-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91de/9699724/3b8338be7093/IJO-62-1-05450-g03.jpg

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Int J Mol Sci. 2025 Jan 4;26(1):376. doi: 10.3390/ijms26010376.
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Abscopal effect in maxillary sinus cancer: Insights from two case reports and a literature review.上颌窦癌的远隔效应：来自两例病例报告及文献复习的见解。
Cancer Rep (Hoboken). 2024 Feb;7(2):e1994. doi: 10.1002/cnr2.1994.
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