Key Laboratory of Optoelectronic Devices and Systems of Guangdong Province & Ministry of Education, College of Physics and Optoelectronic Engineering Shenzhen University, Shenzhen, Guangdong Province, 518060, P. R. China.
Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250100, China.
Biomater Sci. 2022 Dec 20;11(1):119-127. doi: 10.1039/d2bm01455f.
Photodynamic therapy (PDT) has been widely used in preclinical trials for treating various tumors. However, the hypoxic environment of tumors and the limited penetration depth of ultraviolet light severely weaken the PDT effect. To solve the above problems, a near-infrared (NIR) light-triggered oxygen (O) self-supplied phototherapeutic platform (UCNPs/CeO/Ce6/BSA) for amplified PDT performance against solid tumors by alleviating tumor hypoxia has been rationally developed. The platform has excellent stability and can continuously decompose HO for sustained O supply to synergize O generation, thus inducing an enhanced mortality rate (59%) of ID8 cells under hypoxic + HO conditions. The growth of solid tumors was effectively inhibited and the mouse survival rate was dramatically enhanced a superior PDT therapeutic performance. This reported study facilitated the positive development of multifunctional diagnosis and treatment platforms under long-wavelength excitation for O self-supplied tumor treatments.
光动力疗法（PDT）已广泛应用于各种肿瘤的临床前研究。然而，肿瘤的缺氧微环境和紫外线的有限穿透深度严重削弱了 PDT 的效果。为了解决上述问题，合理设计了一种近红外（NIR）光触发的氧（O）自供给光热治疗平台（UCNPs/CeO/Ce6/BSA），通过缓解肿瘤缺氧来增强针对实体瘤的 PDT 性能。该平台具有优异的稳定性，可以持续分解 HO 以持续供应 O，从而协同产生 O，从而在缺氧+HO 条件下将 ID8 细胞的死亡率提高到 59%。有效地抑制了实体瘤的生长，显著提高了小鼠的存活率，表现出优异的 PDT 治疗效果。该研究为长波长激发下的多功能诊断和治疗平台在 O 自供给肿瘤治疗中的应用提供了积极的思路。
