School of Mechanical, Electrical & Information Engineering, Shandong University, No. 180, Wenhua West Road, Weihai, Shandong 264209, China.
Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Electronic Science, East China Normal University, Shanghai 200062, China.
Psychiatry Res Neuroimaging. 2022 Dec;327:111563. doi: 10.1016/j.pscychresns.2022.111563. Epub 2022 Nov 8.
Somatic symptom disorders (SSDs) are common medical disorders characterized by various biological, psychological, and social pathogenic factors. Little is known about the functional profiles associated with SSDs within and between brain networks.
In this study, resting-state functional magnetic resonance imaging (fMRI) was assessed in 60 patients with SSD and 62 matched healthy controls (HCs). Independent component analysis (ICA) of 20 components was conducted and investigated for functional connectivity changes within and acrossnetworks between patients and controls. In addition, fractional amplitudes of low-frequency fluctuation (fALFF) were used to detect intensities of spontaneous functional activity in networks successfully separated by ICA.
The patients with SSD exhibited significantly increased functional connectivity (FC) in the left lingual gyruswithin thevisual network, and higher fALFF values in the cingulate cortex and precuneus within the default network. Furthermore, SSD patients showed significantly decreased FC between the default and visual networks.
SSD is associated with significant changes within thevisual network, and the defaultnetwork, and decreased FC between the default network and visual network, which may indicate an imbalance within and between networks. These decouplings are likely associated with impaired perceptual and self-conscious integration in those with the disease.
躯体症状障碍（SSD）是一种常见的医学疾病，其特征是存在多种生物、心理和社会致病因素。目前尚不清楚 SSD 患者与健康对照组（HC）在脑网络内和网络间的功能特征。
本研究对 60 例 SSD 患者和 62 例匹配的健康对照者（HC）进行了静息态功能磁共振成像（fMRI）评估。对 20 个组件进行独立成分分析（ICA），并对患者和对照组之间的网络内和网络间功能连接变化进行了研究。此外，还使用低频振幅（fALFF）检测 ICA 成功分离的网络中自发性功能活动的强度。
SSD 患者的视觉网络中左侧舌回的功能连接（FC）显著增加，默认网络中的扣带回和楔前叶的 fALFF 值更高。此外，SSD 患者的默认网络和视觉网络之间的 FC 显著降低。
SSD 与视觉网络内以及默认网络内的显著变化以及默认网络和视觉网络之间的 FC 降低有关，这可能表明网络内和网络间的不平衡。这些解耦可能与该疾病患者的感知和自我意识整合受损有关。
