帕金森病痴呆的体内 F-氟洛曲坦 tau 正电子发射断层扫描成像。
In Vivo F-Florzolotau Tau Positron Emission Tomography Imaging in Parkinson's Disease Dementia.
机构信息
Department of Neurology and National Research Center for Aging and Medicine and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.
Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
出版信息
Mov Disord. 2023 Jan;38(1):147-152. doi: 10.1002/mds.29273. Epub 2022 Nov 11.
BACKGROUND
Tau pathology is observed during autopsy in many patients with Parkinson's disease dementia (PDD). Positron emission tomography (PET) imaging using the tracer F-florzolotau has the potential to capture tau accumulation in the living brain.
OBJECTIVE
The aim was to describe the results of F-florzolotau PET/CT (computed tomography) imaging in patients with PDD.
METHODS
Ten patients with PDD, 9 with Parkinson's disease with normal cognition (PD-NC), and 9 age-matched healthy controls (HCs) were enrolled. Clinical assessments and F-florzolotau PET/CT imaging were performed.
RESULTS
F-Florzolotau uptake was significantly higher in the cortical regions of patients with PDD compared with both PD-NC and HCs, especially in the temporal lobe. Notably, F-florzolotau uptake in the occipital lobe of patients with PDD showed a significant correlation with cognitive impairment as reflected by Mini-Mental State Examination (MMSE) scores.
CONCLUSIONS
F-Florzolotau PET imaging can effectively capture the occurrence of tau pathology in patients with PDD, which was also linked to MMSE scores. © 2022 International Parkinson and Movement Disorder Society.
背景
在许多帕金森病痴呆症（PDD）患者的尸检中都观察到 Tau 病理学。使用示踪剂 F-florzolotau 的正电子发射断层扫描（PET）成像有可能在活体大脑中捕获 Tau 积累。
目的
旨在描述 PDD 患者 F-florzolotau PET/CT（计算机断层扫描）成像的结果。
方法
纳入 10 名 PDD 患者、9 名认知正常的帕金森病患者（PD-NC）和 9 名年龄匹配的健康对照者（HCs）。进行临床评估和 F-florzolotau PET/CT 成像。
结果
与 PD-NC 和 HCs 相比，PDD 患者的皮质区域 F-florzolotau 摄取明显更高，尤其是在颞叶。值得注意的是，PDD 患者枕叶的 F-florzolotau 摄取与 Mini-Mental State Examination（MMSE）评分反映的认知障碍呈显著相关性。
结论
F-florzolotau PET 成像可以有效地捕获 PDD 患者 Tau 病理学的发生，这也与 MMSE 评分相关。© 2022 国际帕金森病和运动障碍协会。
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