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对称二叶瓣化修复治疗先天性主动脉瓣或干瓣病变患者。

Symmetric bicuspidizing repair for patients with congenital aortic or truncal valve disease.

机构信息

Department of Cardiac Surgery, Boston Children's Hospital, Boston, Mass.

Department of Cardiac Surgery, Cedars Sinai Medical Center, Los Angeles, Calif.

出版信息

J Thorac Cardiovasc Surg. 2023 Aug;166(2):283-291. doi: 10.1016/j.jtcvs.2022.10.015. Epub 2022 Oct 15.

Abstract

OBJECTIVE

Symmetric bicuspidizing repair has been shown to be safe and effective in the short term in adults and children with unicuspid aortic valve. Outcomes of extending this technique to patients with other forms of aortic and truncal valve disease have not been reported.

METHODS

We performed a retrospective review of patients who underwent the symmetric bicuspidizing repair at Boston Children's Hospital between December 2019 and June 2022 with a contemporary comparator group of patients who underwent other forms of bicuspidization. Survival, valve-related reoperation, and the development of moderate or greater aortic or truncal valve regurgitation were assessed.

RESULTS

There were 23 patients who underwent symmetric bicuspidizing repair and 18 who underwent another form of bicuspidization. Preoperative aortic regurgitation was present in 87.0%. Patients who underwent symmetric bicuspidizing repair more commonly underwent suture annuloplasty (100% vs 55.6%; P = .002) and ascending aortoplasty (78.3% vs 27.8%; P = .004). There was 1 operative mortality (2.4%) in the entire cohort and 1 late mortality. Freedom from moderate aortic regurgitation was 87.5% at 21 months after symmetric bicuspidizing repair compared with 43.5% for patients who underwent other types of bicuspidization; P = .03. Freedom from valve-related reoperation was 100% in the symmetric bicuspidizing repair group compared with 64.4%; P = .02.

CONCLUSIONS

The symmetric bicuspidizing repair may be safely extended to patients with various forms of congenital aortic and truncal valve disease. Longer term follow-up will be necessary to determine the comparative effectiveness of this technique compared with neocuspidization and the Ross procedure.

摘要

目的

在成人和儿童的单叶式主动脉瓣中,对称二瓣化修复在短期内已被证明是安全有效的。将该技术扩展到其他形式的主动脉瓣和干瓣疾病患者的结果尚未报道。

方法

我们对 2019 年 12 月至 2022 年 6 月期间在波士顿儿童医院接受对称二瓣化修复的患者进行了回顾性研究,并与同期接受其他形式二瓣化的患者进行了对比。评估了生存率、与瓣膜相关的再次手术以及中度或更严重的主动脉瓣或干瓣反流的发生情况。

结果

共有 23 例患者接受了对称二瓣化修复,18 例患者接受了另一种形式的二瓣化。术前主动脉瓣反流的发生率为 87.0%。接受对称二瓣化修复的患者更常接受缝合瓣环成形术(100%比 55.6%;P=0.002)和升主动脉成形术(78.3%比 27.8%;P=0.004)。整个队列中有 1 例手术死亡(2.4%)和 1 例晚期死亡。对称二瓣化修复后 21 个月,中度主动脉瓣反流的无事件生存率为 87.5%,而接受其他类型二瓣化的患者为 43.5%;P=0.03。对称二瓣化修复组无瓣膜相关再手术的生存率为 100%,而接受其他类型二瓣化的患者为 64.4%;P=0.02。

结论

对称二瓣化修复可以安全地扩展到各种形式的先天性主动脉瓣和干瓣疾病患者。需要更长时间的随访来确定该技术与新瓣化和罗斯手术相比的比较效果。

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