Altintop Sabri Engin, Unalan-Altintop Tugce, Cihangiroglu Mustafa, Onarer Pelin, Milletli-Sezgin Fikriye, Gozukara Melih, Gozukara Bilge, Zengin Erman
1Suluova State Hospital, Department of Internal Medicine, Amasya, Turkey.
2Department of Medical Microbiology, Amasya University Sabuncuoglu Serefeddin Research and Training Hospital, Amasya, Turkey.
Acta Microbiol Immunol Hung. 2022 Nov 11;69(4):277-282. doi: 10.1556/030.2022.01849. Print 2022 Dec 6.
SARS-CoV-2 virus was initially identified in Wuhan, China, in December 2019 and a global pandemic was declared in March 2020 by World Health Organization. COVID-19 disease is characterized with severe pneumonia and hypoxemia, especially in the elderly population. The elderly population was primarily vaccinated with CoronaVac, which is a whole virion inactivated vaccine (Sinovac Biotech, China) in Turkey. This study aimed to investigate the association of viral load and laboratory parameters with the severity of the disease and vaccination status in elderly (older than 60 years old) COVID-19 patients. The age range of the patients was 61-97 years old with a mean of 71.80. Vaccinated patients had a lower viral load (P = 0.253) in nasopharyngeal swabs during breakthrough COVID-19 infection compared to unvaccinated ones and were hospitalized for a shorter period of time in hospital wards (P = 0.035). A lower number of patients were vaccinated in both moderate (n = 33, 29.20%) and severe/critical group (n = 46, 34.07%) (P = 0.412). Only 17 (32.08%) vaccinated patients were hospitalized in an intensive care unit (ICU), whereas 36 (67.92%) of the ICU patients were unvaccinated (P = 0.931). Severe/critical patients had higher c-reactive protein (CRP), platelet-to-lymphocyte ratio (PLR), fibrinogen, ferritin, and lactate dehydrogenase (LDH) levels compared to the moderate group on the admission day (P < 0.05). Our study suggested that elderly patients vaccinated with CoronaVac had a shorter stay in hospitals and according to our results CRP, PLR, fibrinogen, ferritin, and LDH levels could be used to determine the severity of the infections.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒于2019年12月在中国武汉首次被发现，2020年3月世界卫生组织宣布全球大流行。新型冠状病毒肺炎（COVID-19）疾病的特征是严重肺炎和低氧血症，尤其是在老年人群中。在土耳其，老年人群主要接种的是科兴新冠疫苗（CoronaVac），这是一种全病毒灭活疫苗（中国科兴生物）。本研究旨在调查老年（60岁以上）COVID-19患者的病毒载量和实验室参数与疾病严重程度及疫苗接种状况之间的关联。患者年龄范围为61至97岁，平均年龄为71.80岁。与未接种疫苗的患者相比，接种疫苗的患者在突破性COVID-19感染期间鼻咽拭子中的病毒载量较低（P = 0.253），且在医院病房住院时间较短（P = 0.035）。在中度（n = 33，29.20%）和重度/危重组（n = 46，34.07%）中，接种疫苗的患者数量较少（P = 0.412）。只有17名（32.08%）接种疫苗的患者入住重症监护病房（ICU），而ICU患者中有36名（67.92%）未接种疫苗（P = 0.931）。与中度组相比，重度/危重组患者入院当天的C反应蛋白（CRP）、血小板与淋巴细胞比值（PLR）、纤维蛋白原、铁蛋白和乳酸脱氢酶（LDH）水平更高（P < 0.05）。我们的研究表明，接种科兴新冠疫苗的老年患者住院时间较短，根据我们的结果，CRP、PLR、纤维蛋白原、铁蛋白和LDH水平可用于确定感染的严重程度。
