Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China; School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Zhengzhou University, Zhengzhou, 450001, China; Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China.
Eur J Med Chem. 2023 Jan 5;245(Pt 1):114898. doi: 10.1016/j.ejmech.2022.114898. Epub 2022 Nov 4.
50 New drugs including 36 chemical entities and 14 biologics were approved by the U.S. Food and Drug Administration during 2021. Among the marketed drugs, 31 new small molecule agents (29 small molecule drugs and 2 diagnostic agents) with privileged structures and novel clinical applications represent as promising leads for the development of new drugs with the similar indications and improved therapeutic efficacy. This review is mainly focused on the clinical applications and synthetic methods of 29 small molecule drugs newly approved by the FDA in 2021. We believed that insight into the synthetic approaches of drug molecules would provide creative and practical inspirations for the development of more efficient and practical synthetic technologies to meet with new drug discovery.
2021 年，美国食品和药物管理局批准了 50 种新药，包括 36 种化学实体和 14 种生物制品。在上市的药物中，有 31 种新的小分子药物（29 种小分子药物和 2 种诊断试剂）具有特殊结构和新颖的临床应用，为开发具有类似适应症和改善治疗效果的新药提供了有希望的先导化合物。本文主要综述了 2021 年美国食品和药物管理局批准的 29 种小分子药物的临床应用和合成方法。我们相信，对药物分子合成方法的深入了解将为开发更有效和实用的合成技术以满足新药发现的需求提供创造性和实用的灵感。
