Uniwersytet Medyczny w Łodzi, Klinika Psychiatrii Dorosłych.
Gdański Uniwersytet Medyczny, Wydział Nauk o Zdrowiu, Zakład Pielęgniarstwa Neurologiczno-Psychiatrycznego; Szpital św. Wojciecha w Gdańsku, Oddział Neurologii i Udarowy.
Psychiatr Pol. 2023 Apr 30;57(2):405-419. doi: 10.12740/PP/OnlineFirst/143982.
Migraine and depression often coexist and constitute an important clinical problem. Both disorders are associated with the necessity of chronic treatment, and their mutual coexistence contributes to the phenomenon of drug resistance. Influencing the functioning of patients, they also cause numerous social consequences - affecting the quality of life and achievement of personal goals of patients. This review presents factors that may explain the common pathomechanisms of depression and migraine. Structural and functional disturbances of the central nervous system (CNS), disturbances in the neurotransmitter systems, inflammatory theories, hormonal disturbances, as well as a possible genetic basis were taken into account. Due to the fact that both depression and migraine have a multifactorial etiology and at the present stage of scientific research it is difficult to clearly determine which factor is the most important, such a broad overview has been presented. It is also difficult to determine which of the above-mentioned factors, well documented in international studies, only coexist, and which of them may have a cause-and-effect relationship in the described disorders. Further research into the comorbidity and causes of migraine and depression seems to be worth considering.
偏头痛和抑郁症常常同时存在,构成了一个重要的临床问题。这两种疾病都需要长期治疗,而且它们的共同存在导致了耐药现象。它们影响患者的功能,也会造成许多社会后果,影响患者的生活质量和个人目标的实现。这篇综述介绍了可能解释抑郁和偏头痛共同发病机制的因素。考虑到中枢神经系统(CNS)的结构和功能障碍、神经递质系统紊乱、炎症理论、激素紊乱以及可能的遗传基础。由于抑郁和偏头痛都具有多因素的病因,而且在当前的科学研究阶段,很难明确确定哪个因素是最重要的,因此提出了这样一个广泛的综述。也很难确定上述哪些因素在国际研究中已有充分的记载,只是同时存在,哪些因素可能在描述的疾病中存在因果关系。进一步研究偏头痛和抑郁症的共病和病因似乎值得考虑。