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炎症免疫视角下八种偏头痛风险因素与偏头痛的关联：一项多组学孟德尔随机化研究

Inflammo-immune perspective on the association of eight migraine risk factors with migraine: a multi-omics Mendelian randomization study.

作者信息

Zhao Jiaxi, Chen Rong, Luo Mengqi, Gong Hongping, Li Kaixin, Zhao Qian

机构信息

General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

出版信息

Front Neurol. 2024 Aug 7;15:1440995. doi: 10.3389/fneur.2024.1440995. eCollection 2024.

DOI:10.3389/fneur.2024.1440995
PMID:39170074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11335614/
Abstract

BACKGROUND

Migraine risk factors are associated with migraine susceptibility, yet their mechanisms are unclear. Evidence suggests a role for inflammatory proteins and immune cells in migraine pathogenesis. This study aimed to examine the inflammo-immune association between eight migraine risk factors and the disorder.

METHODS

This study utilized inverse variance weighted (IVW) method and colocalization analysis to explore potential causal relationships between eight migraine risk factors, migraine, 731 immune cells, and 91 circulating inflammatory proteins. Mediation Mendelian randomization (MR) was further used to confirm the mediating role of circulating inflammatory proteins and immune cells between the eight migraine risk factors and migraine.

RESULTS

Migraine risk factors are linked to 276 immune cells and inflammatory proteins, with cigarettes smoked per day strongly co-localized with CD33-HLA DR+ cells. Despite no co-localization, 23 immune cells/inflammatory proteins relate to migraine. Depression, all anxiety disorders, and sleep apnea are correlated with migraine, and all anxiety disorders are supported by strong co-localization evidence. However, the mediating effect of inflammatory proteins and immune cells between eight migraine risk factors and migraine has not been confirmed.

CONCLUSION

We elucidate the potential causal relationships between eight migraine risk factors, migraine, immune cells, and inflammatory proteins, enhancing our understanding of the molecular etiology of migraine pathogenesis from an inflammatory-immune perspective.

摘要

背景

偏头痛风险因素与偏头痛易感性相关，但其机制尚不清楚。有证据表明炎症蛋白和免疫细胞在偏头痛发病机制中起作用。本研究旨在探讨八种偏头痛风险因素与该疾病之间的炎症-免疫关联。

方法

本研究采用逆方差加权（IVW）方法和共定位分析，以探索八种偏头痛风险因素、偏头痛、731种免疫细胞和91种循环炎症蛋白之间的潜在因果关系。进一步使用中介孟德尔随机化（MR）来确认循环炎症蛋白和免疫细胞在八种偏头痛风险因素与偏头痛之间的中介作用。

结果

偏头痛风险因素与276种免疫细胞和炎症蛋白相关，每天吸烟量与CD33-HLA DR+细胞高度共定位。尽管没有共定位，但23种免疫细胞/炎症蛋白与偏头痛有关。抑郁症、所有焦虑症和睡眠呼吸暂停与偏头痛相关，且所有焦虑症都有强有力的共定位证据支持。然而，炎症蛋白和免疫细胞在八种偏头痛风险因素与偏头痛之间的中介作用尚未得到证实。

结论

我们阐明了八种偏头痛风险因素、偏头痛、免疫细胞和炎症蛋白之间的潜在因果关系，从炎症-免疫角度增强了我们对偏头痛发病机制分子病因的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d7/11335614/36f5b32a44a6/fneur-15-1440995-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d7/11335614/2fdbb306dcd5/fneur-15-1440995-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d7/11335614/c2de6644586e/fneur-15-1440995-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d7/11335614/c096ef2e7d12/fneur-15-1440995-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d7/11335614/36f5b32a44a6/fneur-15-1440995-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d7/11335614/2fdbb306dcd5/fneur-15-1440995-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d7/11335614/c2de6644586e/fneur-15-1440995-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d7/11335614/c096ef2e7d12/fneur-15-1440995-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d7/11335614/36f5b32a44a6/fneur-15-1440995-g005.jpg

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