Institute of Animal Husbandry and Veterinary Science, Shanghai Academy of Agricultural Sciences, Shanghai 201106, Shanghai, China.
Key Laboratory of Agricultural Genetics and Breeding, Biotechnology Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai 201106, Shanghai, China.
Life Sci. 2023 Jan 1;312:121162. doi: 10.1016/j.lfs.2022.121162. Epub 2022 Nov 11.
Mitochondrial dysfunction has been hypothesized to play a central role in the pathobiology of nonalcoholic fatty liver disease (NAFLD). Thus, maintenance of mitochondria homeostasis and function is important for NAFLD treatment. Mitophagy, a process that selectively clears damaged or dysfunctional mitochondria through autophagic machinery, is beneficial for mitochondrial homeostasis. Notably, strategies that regulate mitophagy exert beneficial effects in preclinical experiments. Traditional Chinese medicine (TCM) is a natural product including active ingredients, extracts, and has great potential in the prevention and treatment of liver diseases. Given the importance of mitophagy, this review summarizes mitophagy-related pathways and the latest findings on the regulation of mitophagy in NAFLD. We also highlight the potential of TCM targeting mitophagy for the treatment of NAFLD.
线粒体功能障碍被认为在非酒精性脂肪性肝病（NAFLD）的病理生物学中起核心作用。因此，维持线粒体的动态平衡和功能对于 NAFLD 的治疗很重要。自噬是一种通过自噬机制选择性清除受损或功能失调的线粒体的过程，有利于线粒体的动态平衡。值得注意的是，调节自噬的策略在临床前实验中具有有益的效果。中药（TCM）是一种天然产物，包括活性成分、提取物，在防治肝脏疾病方面具有巨大的潜力。鉴于自噬的重要性，本综述总结了与自噬相关的途径以及 NAFLD 中自噬调节的最新发现。我们还强调了 TCM 靶向自噬治疗 NAFLD 的潜力。
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