Déchelle-Marquet Paul-Alexandre, Guillonneau Xavier, Sennlaub Florian, Delarasse Cécile
Sorbonne University, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France.
Sorbonne University, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France.
Neuropharmacology. 2023 Feb 1;223:109332. doi: 10.1016/j.neuropharm.2022.109332. Epub 2022 Nov 11.
Adenosine triphosphate (ATP) is a signalling molecule acting as a neurotransmitter but also as a danger signal. The purinergic receptor P2X7 is the main sensor of high concentration of ATP released by damaged cells. In the eye, P2X7 is expressed by resident microglia and immune cells that infiltrate the retina in disease such as age-related macular degeneration (AMD), a degenerative retinal disease, and uveitis, an inflammatory eye disease. Activation of P2X7 is involved in several physiological and pathological processes: phagocytosis, activation of the inflammasome NLRP3, release of pro-inflammatory mediators and cell death. The aim of this review is to discuss the potential involvement of P2X7 in the development of AMD and uveitis.
三磷酸腺苷（ATP）是一种信号分子，既作为神经递质，也作为危险信号。嘌呤能受体P2X7是受损细胞释放的高浓度ATP的主要传感器。在眼睛中，P2X7由常驻小胶质细胞和免疫细胞表达，这些细胞在诸如年龄相关性黄斑变性（AMD，一种视网膜退行性疾病）和葡萄膜炎（一种眼部炎症性疾病）等疾病中浸润视网膜。P2X7的激活参与多种生理和病理过程：吞噬作用、炎性小体NLRP3的激活、促炎介质的释放和细胞死亡。本综述的目的是讨论P2X7在AMD和葡萄膜炎发展中的潜在作用。
