Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Methods Mol Biol. 2023;2580:3-24. doi: 10.1007/978-1-0716-2740-2_1.
T lymphocytes (T cells) are essential components of the adaptive immune system; they serve multiple functions in responses to pathogens and to ensure immune homeostasis. Written for readers first entering this field of study, this chapter is a brief overview of the development of T cells in the thymus, from the entry of thymus-settling bone marrow-derived precursors to the egress of mature T cells. Surveyed topics include the differentiation and expansion of early precursors, the generation of the T cell antigen receptor repertoire, the selection of αβ T cell precursors, and their acquisition of functional competency.
T 淋巴细胞（T 细胞）是适应性免疫系统的重要组成部分；它们在应对病原体和确保免疫稳态方面具有多种功能。本章面向初次涉足该研究领域的读者，简要概述了 T 细胞在胸腺中的发育过程，从进入胸腺定居的骨髓源性前体细胞到成熟 T 细胞的迁出。综述的主题包括早期前体细胞的分化和扩增、T 细胞抗原受体库的产生、αβ T 细胞前体的选择以及它们获得功能能力的过程。
