韩国 2006-2020 年 3 个月以下婴儿侵袭性细菌感染病因变化。

Changes in Etiology of Invasive Bacterial Infections in Infants Under 3 Months of Age in Korea, 2006-2020.

机构信息

Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.

Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

出版信息

Pediatr Infect Dis J. 2022 Dec 1;41(12):941-946. doi: 10.1097/INF.0000000000003714. Epub 2022 Sep 20.

DOI:10.1097/INF.0000000000003714

PMID:36375095

Abstract

OBJECTIVES

Invasive bacterial infection (IBI) causes a significant burden in infants. In this study, we analyzed changes in epidemiology of IBI among infants in Korea.

METHODS

A retrospective multicenter-based surveillance for IBIs in infants <3 months of age was performed during 2006-2020. Cases were classified as an early-onset disease (EOD) (0-6 days) or late-onset disease (LOD) (7-89 days). The temporal trend change in proportion of pathogens was analyzed.

RESULTS

Among 1545 cases, the median age was 28 days (IQR: 12, 53) and EOD accounted for 17.7%. Among pathogens, S. agalactiae (40.4%), E. coli (38.5%), and S. aureus (17.8%) were the most common and attributed for 96.7%. Among EOD (n = 274), S. agalactiae (45.6%), S. aureus (31.4%), E. coli (17.2%) and L. monocytogenes (2.9%) were most common. Among LOD (n = 1274), E. coli (43.1%), S. agalactiae (39.3%), S. aureus (14.9%) and S. pneumoniae (1.3%) were most common. In the trend analysis, the proportion of S. aureus (r s = -0.850, P < 0.01) decreased significantly, while that of S. agalactiae increased (r s = 0.781, P < 0.01).

CONCLUSION

During 2006-2020, among IBI in infants <3 months of age, S. agalactiae, E. coli, and S. aureus were most common and an increasing trend of S. agalactiae was observed.

摘要

目的

侵袭性细菌感染（IBI）给婴儿带来了巨大负担。本研究分析了韩国婴儿 IBI 流行病学的变化。

方法

对 2006-2020 年期间 3 个月以下婴儿的 IBI 进行了回顾性多中心监测。病例分为早发性疾病（EOD）（0-6 天）或晚发性疾病（LOD）（7-89 天）。分析病原体比例的时间趋势变化。

结果

在 1545 例病例中，中位年龄为 28 天（IQR：12，53），EOD 占 17.7%。病原体中，无乳链球菌（40.4%）、大肠埃希菌（38.5%）和金黄色葡萄球菌（17.8%）最为常见，占 96.7%。在 EOD（n=274）中，无乳链球菌（45.6%）、金黄色葡萄球菌（31.4%）、大肠埃希菌（17.2%）和单核细胞增生李斯特菌（2.9%）最为常见。在 LOD（n=1274）中，大肠埃希菌（43.1%）、无乳链球菌（39.3%）、金黄色葡萄球菌（14.9%）和肺炎链球菌（1.3%）最为常见。在趋势分析中，金黄色葡萄球菌的比例（r s=-0.850，P<0.01）显著下降，而无乳链球菌的比例则增加（r s=0.781，P<0.01）。