Moein Mahini Seyed, Younesi Mohammad, Mortazavi Ghazal, Samare-Najaf Mohammad, Karim Azadbakht Mohammad, Jamali Navid
Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Biochemistry Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Clin Chim Acta. 2023 Jan 1;538:70-86. doi: 10.1016/j.cca.2022.11.013. Epub 2022 Nov 12.
Endometriosis, a benign gynecologic and chronic inflammatory disease, is defined by the presence of endometrial tissue outside the uterus characterized mainly by pelvic pain and infertility. Because endometriosis affects approximately 10% of females, it represents a significant socioeconomic burden worldwide having tremendous impact on daily quality of life. Accurate and prompt diagnosis is crucial for the management of this debilitating disorder. Unfortunately, diagnosis is typically delayed to lack of specific symptoms and readily accessible biomarkers. Although histopathologic examination remains the current gold standard, this approach is highly invasive and not applicable for early screening. Recent work has focused on the identification of reliable biomarkers including immunologic, ie, immune cells, antibodies and cytokines, as well as genetic and biochemical markers, ie, microRNAs, lncRNAs, circulating and mitochondrial nucleic acids, along with some hormones, glycoproteins and signaling molecules. Confirmatory research studies are, however, needed to more fully establish these markers in the diagnosis, progression and staging of these endometrial lesions.
子宫内膜异位症是一种良性妇科慢性炎症性疾病，其定义为子宫外存在子宫内膜组织，主要特征为盆腔疼痛和不孕。由于子宫内膜异位症影响约10%的女性，它在全球范围内构成了重大的社会经济负担，对日常生活质量产生巨大影响。准确及时的诊断对于管理这种使人衰弱的疾病至关重要。不幸的是，由于缺乏特异性症状和易于获取的生物标志物，诊断通常会延迟。尽管组织病理学检查仍是目前的金标准，但这种方法具有高度侵入性，不适用于早期筛查。最近的工作集中在鉴定可靠的生物标志物，包括免疫学标志物，即免疫细胞、抗体和细胞因子，以及遗传和生化标志物，即微小RNA、长链非编码RNA、循环和线粒体核酸，还有一些激素、糖蛋白和信号分子。然而，需要进一步的研究来更全面地确立这些标志物在这些子宫内膜病变的诊断、进展和分期中的作用。
