Key Laboratory of Pharmaceutical Quality Control of Hebei Province, School of Pharmaceutical Sciences, Hebei University, Baoding 071000, China.
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, School of Pharmaceutical Sciences, Hebei University, Baoding 071000, China.
J Control Release. 2022 Dec;352:946-960. doi: 10.1016/j.jconrel.2022.11.018. Epub 2022 Nov 16.
Arthritis is a kind of chronic disease that affects joints and muscles with the symptoms of joint pain, inflammation and limited movement of joints. Among various clinical therapies, drug therapy has been extensively applied because of its accessibility, safety and effectiveness. In recent years, the intra-articular injection has dramatic therapeutic effects in treating arthritis with high patient compliance and low side effects. In this review, we will introduce pathology of arthritis, along with the accessible treatment and diagnosis methods, then we will summarize major advances of current hopeful intra-articular delivery systems such as microspheres, hydrogels, nanoparticles and liposomes. At last, some safety assessments in the preclinical work and the main challenges for the further development of intra-articular treatment were also discussed.
关节炎是一种影响关节和肌肉的慢性疾病，其症状包括关节疼痛、炎症和关节活动受限。在各种临床治疗方法中，药物治疗因其可及性、安全性和有效性而得到广泛应用。近年来，关节内注射在治疗关节炎方面具有显著的疗效，患者顺应性高，副作用低。在这篇综述中，我们将介绍关节炎的病理学，以及可及的治疗和诊断方法，然后总结当前有希望的关节内递药系统如微球、水凝胶、纳米颗粒和脂质体的主要进展。最后，还讨论了临床前工作中的一些安全性评估以及关节内治疗进一步发展的主要挑战。
