髂骨镶嵌移植后性激素与新骨形成率的相关性：一项前瞻性临床初步研究。
Association of sex steroid hormones and new bone formation rate after iliac onlay grafting: a prospective clinical pilot study.
机构信息
Department of Oral and Maxillofacial Surgery, Center for Dental Medicine, Medical Center - University of Freiburg, Faculty of Medicine - University of Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany.
Department of Oral and Maxillofacial Surgery, Berlin Institute of Health, Corporate Member of Freie Universität Berlin, Charité - Universitätsmedizin Berlin, Humboldt-Universität Zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
出版信息
Int J Implant Dent. 2022 Nov 15;8(1):53. doi: 10.1186/s40729-022-00447-x.
PURPOSE
The present prospective study evaluates the association between new bone formation rate in the iliac onlay graft and sex steroid hormone serum levels.
METHODS
A total of 15 partially or completely edentulous postmenopausal females and 9 males with less than 5 mm height of the remaining alveolar bone underwent iliac onlay grafting followed by dental implant placement using a two-stage approach. Sex hormone binding globulin and 17β-estradiol serum levels were investigated by electrochemiluminescence immunoassay, while total testosterone level was analyzed using radioimmunoassay. At the time of implant placement, 12 weeks after grafting, bone biopsies were obtained and analyzed histomorphometrically. Statistical analysis was performed using linear mixed models.
RESULTS
Grafting procedure was successfully performed in all patients. The mean new bone formation rate was 32.5% (116 samples). In men the mean new bone formation rate (38.1%) was significantly higher (p < 0.01) than in women (27.6%). Independent of gender 17β-estradiol and testosterone were positively associated to overall new bone formation rate, albeit a significant influence was only seen for 17β-estradiol in men (p = 0.020). Sex hormone binding globulin had no influence on new bone formation rate (p = 0.897). There was no significant association between new bone formation rate and age (p = 0.353) or new bone formation rate and body mass index (p = 0.248).
CONCLUSION
Positive association of 17ß-estradiol as well as testosterone with new bone formation rate after iliac onlay grafting indicates a role of sex steroid hormones in alveolar bone regeneration, although the observed influence was only significant for 17ß-estradiol in men.
目的
本前瞻性研究评估了髂骨骨板移植中新骨形成率与性激素血清水平之间的关系。
方法
15 名部分或完全无牙的绝经后女性和 9 名牙槽骨剩余高度小于 5mm 的男性患者接受髂骨骨板移植，随后采用两阶段方法进行牙种植体植入。采用电化学发光免疫分析法检测性激素结合球蛋白和 17β-雌二醇血清水平，放射免疫分析法检测总睾酮水平。在种植体植入时（移植后 12 周），获取骨活检并进行组织形态计量学分析。采用线性混合模型进行统计分析。
结果
所有患者均成功完成了移植手术。平均新骨形成率为 32.5%（116 个样本）。男性的平均新骨形成率（38.1%）明显高于女性（27.6%）（p<0.01）。独立于性别，17β-雌二醇和睾酮与总体新骨形成率呈正相关，尽管仅在男性中观察到 17β-雌二醇具有显著影响（p=0.020）。性激素结合球蛋白对新骨形成率无影响（p=0.897）。新骨形成率与年龄（p=0.353）或新骨形成率与体重指数（p=0.248）之间无显著相关性。
结论
髂骨骨板移植后 17β-雌二醇和睾酮与新骨形成率呈正相关，表明性激素在牙槽骨再生中起作用，尽管仅在男性中观察到 17β-雌二醇的影响具有统计学意义。
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