Department of Gynecological Oncology Surgery, Faculty of Medicine, Uludag University, Bursa, Turkey.
Department of Obstetrics & Gynecology, Bursa Yuksek Ihtisas Training & Research Hospital, University of Health Sciences, Bursa, Turkey.
J Coll Physicians Surg Pak. 2022 Nov;32(11):1404-1409. doi: 10.29271/jcpsp.2022.11.1404.
To determine the role of complete blood count and coagulation function factors as inflammatory markers in intrahepatic cholestasis of pregnancy (ICP).
Descriptive, analytical study.
Department of Obstetrics and Gynecology, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey, between January 2018 and 2021.
This study was conducted with a total of 200 pregnant women, 80 with ICP and 120 control healthy pregnant women. The diagnosis of ICP was made based on elevated liver enzymes and bile acids (≥10 μmol/L) and pruritis. Routine complete blood count parameters and coagulation function tests were compared between both groups. ROC analyses were used to analyse the predictive value of fibrinogen levels in ICP. Spearman's rank correlation analysis assessed the correlation between fasting bile acid value and complete blood count and coagulation parameters.
Neutrophil-lymphocyte ratio (NLR), Platelet count, and Platecrit levels were significantly higher in the ICP group, and red blood cell distribution width (RDW) was lower than in the healthy group (p <0.05). The median plasma fibrinogen value was 571 mg/dl which was significantly higher in pregnant women with cholestasis (p <0.001). The prothrombin time and international normalized ratio (INR) values were also significantly different in each group (p <0.001 and 0.013, respectively). In addition, platelet distribution width (PDW), plasma fibrinogen, and prothrombin time (PT) showed significant association with the bile acid values (p values=0.007, 0.03, and 0.04 respectively). Each 1-unit elevation of the fibrinogen increased the risk of cholestasis by 1.02 times. There was a positive correlation of 0.24-fold between the plasma fibrinogen value and acids.
The plasma fibrinogen value was the highest predictor of cholestasis diagnosis by analyzing blood parameters. Elevated fibrinogen levels correlated with bile acid levels, can potentially detect ICP.
Bile acids, Cholestasis, Coagulation function parameters, Fibrinogen levels, Inflammation.
确定全血细胞计数和凝血功能因子作为妊娠肝内胆汁淤积症（ICP）炎症标志物的作用。
描述性、分析性研究。
土耳其布尔萨 Yüksek İhtisas 培训和研究医院妇产科，2018 年 1 月至 2021 年。
这项研究共纳入了 200 名孕妇，80 名 ICP 患者和 120 名健康孕妇。ICP 的诊断基于肝酶和胆汁酸升高（≥10 μmol/L）和瘙痒。比较两组常规全血细胞计数参数和凝血功能试验。使用 ROC 分析来分析纤维蛋白原水平在 ICP 中的预测价值。Spearman 秩相关分析评估了空腹胆汁酸值与全血细胞计数和凝血参数之间的相关性。
ICP 组的中性粒细胞-淋巴细胞比值（NLR）、血小板计数和血小板压积水平显著升高，红细胞分布宽度（RDW）水平低于健康组（p<0.05）。血浆纤维蛋白原的中位数为 571mg/dl，在胆淤积的孕妇中显著升高（p<0.001）。凝血酶原时间和国际标准化比值（INR）值在各组之间也有显著差异（p<0.001 和 0.013）。此外，血小板分布宽度（PDW）、血浆纤维蛋白原和凝血酶原时间（PT）与胆汁酸值显著相关（p 值分别为 0.007、0.03 和 0.04）。纤维蛋白原每升高 1 个单位，胆淤积的风险增加 1.02 倍。血浆纤维蛋白原值与酸之间存在 0.24 倍的正相关。
通过分析血液参数，纤维蛋白原值是诊断胆淤积的最高预测因子。升高的纤维蛋白原水平与胆汁酸水平相关，可能有助于检测 ICP。
胆汁酸、胆淤积、凝血功能参数、纤维蛋白原水平、炎症。
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