中性粒细胞与淋巴细胞比值作为妊娠期肝内胆汁淤积症的诊断标志物。
Neutrophil-to-lymphocyte ratio as a diagnostic marker of intrahepatic cholestasis of pregnancy.
作者信息
Kirbas Ayse, Biberoglu Ebru, Daglar Korkut, İskender Cantekin, Erkaya Salim, Dede Hülya, Uygur Dilek, Danisman Nuri
机构信息
Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2014 Sep;180:12-5. doi: 10.1016/j.ejogrb.2014.05.042. Epub 2014 Jun 13.
INTRODUCTION
In this study, we aimed to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and total bile acid (TBA) concentration in pregnant women with intrahepatic cholestasis of pregnancy (ICP).
MATERIALS AND METHODS
Fasting and postprandial TBA, NLR, and aminotransferase (AST/ALT) levels in the blood samples of 65 pregnant women with intrahepatic cholestasis were examined in this prospective case-control study. Thirty-three of the patients had mild disease and 32 had severe disease; 70 healthy women in uncomplicated pregnancies served as the control group.
RESULTS
Not only was the mean NLR elevated in the pregnant women with cholestasis when compared to the controls, but it also predicted the severity of the cholestasis. The correlation between fasting TBA and NLR was significant.
COMMENTS
Although TBA is still the diagnostic standard, NLR can be used as an initial screening tool due to its high specificity.
引言
在本研究中，我们旨在调查妊娠肝内胆汁淤积症（ICP）孕妇的中性粒细胞与淋巴细胞比值（NLR）和总胆汁酸（TBA）浓度之间的关系。
材料与方法
在这项前瞻性病例对照研究中，检测了65例妊娠肝内胆汁淤积症孕妇血液样本中的空腹和餐后TBA、NLR及转氨酶（AST/ALT）水平。其中33例患者病情较轻，32例病情严重；70例无并发症的健康孕妇作为对照组。
结果
与对照组相比，胆汁淤积症孕妇的平均NLR不仅升高，而且它还能预测胆汁淤积症的严重程度。空腹TBA与NLR之间的相关性显著。
评论
尽管TBA仍是诊断标准，但由于NLR具有高特异性，它可作为一种初步筛查工具。
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