White John P M, Cibelli Mario, Nagy Istvan, Nilius Bernd, McGeown James Graham
Anaesthetics, Pain Medicine and Intensive Care Division, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK.
Department of Anaesthetics, The Queen Elizabeth Hospital, Birmingham, UK.
Rev Physiol Biochem Pharmacol. 2023;186:57-93. doi: 10.1007/112_2022_75.
Transient receptor potential vanilloid type 4 (TRPV4) channels are Ca-permeable non-selective cation channels which mediate a wide range of physiological functions and are activated and modulated by a diverse array of stimuli. One of this ion channel's least discussed functions is in relation to the generation and maintenance of certain pain sensations. However, in the two decades which have elapsed since the identification of this ion channel, considerable data has emerged concerning its function in mediating pain sensations. TRPV4 is a mediator of mechanical hyperalgesia in the various contexts in which a mechanical stimulus, comprising trauma (at the macro-level) or discrete extracellular pressure or stress (at the micro-level), results in pain. TRPV4 is also recognised as constituting an essential component in mediating inflammatory pain. It also plays a role in relation to many forms of neuropathic-type pain, where it functions in mediating mechanical allodynia and hyperalgesia.Here, we review the role of TRPV4 in mediating pain sensations.
瞬时受体电位香草酸亚型4（TRPV4）通道是钙离子通透的非选择性阳离子通道，介导多种生理功能，并受到多种刺激的激活和调节。该离子通道最少被讨论的功能之一与某些痛觉的产生和维持有关。然而，自该离子通道被发现后的二十年里，出现了大量关于其在介导痛觉方面功能的数据。在各种情况下，包括创伤（宏观层面）或离散的细胞外压力或应力（微观层面）等机械刺激导致疼痛时，TRPV4是机械性痛觉过敏的介质。TRPV4也被认为是介导炎症性疼痛的重要组成部分。它在多种形式的神经病理性疼痛中也起作用，介导机械性异常性疼痛和痛觉过敏。在此，我们综述TRPV4在介导痛觉中的作用。
