Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, 563003, Guizhou, China.
The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, China.
Mol Cell Biochem. 2023 Jun;478(6):1397-1410. doi: 10.1007/s11010-022-04602-1. Epub 2022 Nov 15.
The inflammasome is a multimeric protein complex located in the cytoplasm that is activated by many factors and subsequently promotes the release of proinflammatory factors such as interleukin (IL)-1β and IL-18, resulting in a series of inflammatory responses that ultimately lead to the occurrence of various diseases. The Nod-like receptor protein 3 (NLRP3) inflammasome is the most characteristic type and the most widely studied among many inflammasomes. Activation of the NLRP3 inflammasome is closely related to the occurrence of many diseases, such as Alzheimer's disease. At present, a large number of studies have focused on the mechanisms underlying the activation of the NLRP3 inflammasome. Plenty of articles have reported the activation of the NLRP3 inflammasome by various ions, such as K and Na reflux and Ca influx. However, few articles have reviewed the effects of various ion channels on the activation of the NLRP3 inflammasome and the relationship between the diseases caused by these proteins. This article mainly summarizes the relationship between intracellular and extracellular ion activities and ion channels and the activation of the NLRP3 inflammasome. We also provide a general summary of the diseases of each system caused by NLRP3 activation. We hope that more research will provide options for the treatment of diseases driven by the NLRP3 inflammasome.
炎症小体是一种位于细胞质中的多聚体蛋白复合物，可被多种因素激活，随后促进促炎因子（如白细胞介素-1β和白细胞介素-18）的释放，从而引发一系列炎症反应，最终导致各种疾病的发生。Nod 样受体蛋白 3（NLRP3）炎症小体是多种炎症小体中最具特征性和研究最广泛的一种。NLRP3 炎症小体的激活与许多疾病的发生密切相关，如阿尔茨海默病。目前，大量研究集中在 NLRP3 炎症小体激活的机制上。大量文章报道了各种离子（如 K 和 Na 反流和 Ca 内流）激活 NLRP3 炎症小体。然而，很少有文章综述了各种离子通道对 NLRP3 炎症小体激活的影响以及这些蛋白引起的疾病之间的关系。本文主要总结了细胞内和细胞外离子活动和离子通道与 NLRP3 炎症小体激活的关系。我们还对 NLRP3 激活引起的每个系统的疾病进行了概括总结。我们希望更多的研究能够为 NLRP3 炎症小体驱动的疾病治疗提供选择。
