AL-NAHRAIN UNIVERSITY, BAGHDAD, IRAQ.
Wiad Lek. 2022;75(9 pt 2):2222-2225. doi: 10.36740/WLek202209208.
The aim: To understand the effects of COVID-19 infection on gonadotropins and sex steroid hormones in males.
Materials and methods: This is a cohort study conducted in fifty males, who had been previously infected with COVID-19 with normal hormonal profile. Fifty Iraqi males were attending the male clinic at Higher Institute of Infertility Diagnosis and Assisted Reproductive Technologies, diagnosed with standard methods. The assessment of serum hormonal levels including (FSH, LH, Prolactin and Testosterone) was done 3 times: 1st time after one-month post recovery after COVID-19, 2nd time after 2 months post recovery and 3rd time - after 3 months post recovery.
Results: There was no significant change in the mean level of serum FSH during the first, second and third months (p = 0.630). LH serum level was highly significantly reduced during follow up (p< 0.001). Serum prolactin level, reduced significantly during follow up (p< 0.001). Serum testosterone level was the lowest in the first month and increased during the second month and then during the third month in a highly significant manner (p< 0.001).
Conclusions: Sub-clinical hypogonadism may be suspected as a consequence of COVID-19 infection in males as its first presentation characterized by increased LH & decreased testosterone production.
了解 COVID-19 感染对男性促性腺激素和性激素的影响。
这是一项在 50 名先前感染过 COVID-19 且激素谱正常的男性中进行的队列研究。50 名伊拉克男性在高等不孕诊断和辅助生殖技术研究所的男性诊所就诊，采用标准方法进行诊断。评估血清激素水平，包括（FSH、LH、催乳素和睾酮），共进行 3 次：COVID-19 后 1 个月恢复后第 1 次、恢复后 2 个月第 2 次、恢复后 3 个月第 3 次。
血清 FSH 的平均水平在第 1、2 和第 3 个月均无显著变化（p = 0.630）。LH 血清水平在随访期间显著降低（p < 0.001）。血清催乳素水平在随访期间显著降低（p < 0.001）。血清睾酮水平在第 1 个月最低，在第 2 个月和第 3 个月显著增加（p < 0.001）。
男性 COVID-19 感染后的最初表现为 LH 升高和睾酮生成减少，可能提示存在亚临床性腺功能减退症。
