Sitaras Ioannis, Jacobsen Henning, Higdon Melissa M, Dowling William E, Bar-Zeev Naor, Deloria Knoll Maria
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Department of Viral Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
NPJ Vaccines. 2022 Nov 15;7(1):147. doi: 10.1038/s41541-022-00565-y.
Virus neutralization data using post-vaccination sera are an important tool in informing vaccine use policy decisions, however, they often pose interpretive challenges. We systematically reviewed the pre-print and published literature for neutralization studies against Omicron using sera collected after both primary and booster vaccination. We found a high proportion of post-primary vaccination sera were not responding against Omicron but boosting increased both neutralizing activity and percent of responding sera. We recommend reporting percent of responders alongside neutralization data to portray vaccine neutralization ability more accurately.
使用接种疫苗后血清的病毒中和数据是为疫苗使用政策决策提供信息的重要工具，然而，它们常常带来解释方面的挑战。我们系统地回顾了预印本和已发表的文献，以查找针对使用初次和加强接种后采集的血清对奥密克戎进行中和研究的情况。我们发现，很大一部分初次接种疫苗后的血清对奥密克戎无反应，但加强接种增加了中和活性以及有反应血清的比例。我们建议在报告中和数据的同时报告有反应者的比例，以便更准确地描述疫苗的中和能力。
