Ferrari Roberto, Cimaglia Paolo, Rapezzi Claudio, Tavazzi Luigi, Guardigli Gabriele
Cardiovascular Research Centre, Ferrara University, Via Aldo Moro 8, Ferrara 44124, Italy.
Cardiovascular Department, GVM Care and Research, Maria Cecilia Hospital, Via Corriera 1, Cotignola, RA 48033, Italy.
Eur Heart J Suppl. 2022 Nov 11;24(Suppl H):H3-H7. doi: 10.1093/eurheartjsupp/suac057. eCollection 2022 Nov.
Cardiovascular disease (CVD) is a chronic condition driven by the complex interaction of different risk factors including genetics, lifestyle, environment, etc. which, differently from other pathologies, can be prevented. Treatment of CVD has been inconceivably successful but now it seems that it has reached a plateau suggesting that prevention is the way forward. However, the COVID-19 pandemic has spotted all the limits of the actual health system regarding territorial and, particularly, of preventive medicine. To this end, recently, the SCORE2 risk prediction algorithms, a contemporary model to estimate 10-years risk of CVD in Europe and the new guidelines on prevention have been released. The present review article describes a dream: how prevention of CVD should be addressed in the future. New concepts and paradigms like early genetically personalized and imaging driven risk factors, cardiac risk cartography, measurements of the exposome, estimation of costs of a delayed outcome vs. healthy lifespan, are all addressed. We highlight the importance of technologies and the concept of being engaged in a '' and not just '' system as it is today. The concept of '' with a '' instead of a '' is described. Finally, we articulate the four points necessary for the dream to come true.
心血管疾病(CVD)是一种由多种风险因素(包括遗传、生活方式、环境等)复杂相互作用驱动的慢性疾病,与其他疾病不同的是,它是可以预防的。心血管疾病的治疗取得了令人难以置信的成功,但现在似乎已达到一个平台期,这表明预防才是前进的方向。然而,新冠疫情暴露了当前卫生系统在地域方面,尤其是预防医学方面的所有局限性。为此,最近发布了SCORE2风险预测算法,这是一种用于估计欧洲心血管疾病10年风险的当代模型以及新的预防指南。本篇综述文章描述了一个愿景:未来应如何开展心血管疾病的预防工作。文中探讨了一些新的概念和范式,如早期基因个性化和影像学驱动的风险因素、心脏风险制图、暴露组测量、延迟结果成本与健康寿命的估计等。我们强调了技术的重要性以及参与一个“而非仅仅是”如今这样的“系统”的概念。文中描述了“拥有一个‘’而非一个‘’”的概念。最后,我们阐述了实现这一愿景所需的四个要点。