尼日利亚家鸽MC1R变异与羽毛颜色多样性的关联（）。（注：括号内容原文缺失，翻译时保留原样）

Association of MC1R variation and plumage color diversity of Nigerian domestic pigeon ().

作者信息

Jiang Xiang-Xiang, Adeola Adeniyi Charles, Sola-Ojo Foluke Eunice, Abubakar Ibraheem Atolagbe, Fatima Isiaka Hannah, Olaoluwa Ojuerayetan Judah, Abodurin Abdulwahab Barakat, Olasunkanmi Olawale Abdulafeez, Abisola Oladejo Hafsat, Uthman Oladipo, Kehinde Adeshina Esther, Hamidat Hussein, Nishola Taiwo Eyitayo, Bello Semiu Folaniyi, Peng Min-Sheng, Zhang Ya-Ping

机构信息

College of Life Sciences, Anhui Normal University, Wuhu, China.

State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.

出版信息

J Adv Vet Anim Res. 2022 Sep 29;9(3):369-373. doi: 10.5455/javar.2022.i604. eCollection 2022 Sep.

DOI:10.5455/javar.2022.i604

PMID:36382035

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9597907/

Abstract

OBJECTIVES

Domestic pigeons () have diverse plumage pigmentations. Melanocortin 1 receptor () gene variation has been correlated with color traits. The association between and plumage coloration in African domestic pigeons is yet to be investigated.

MATERIALS AND METHODS

Herein, we report the relationships between single nucleotide polymorphisms (SNPs) in and plumage of 35 domestic pigeons from Nigeria with 4 different plumage phenotypes plus 37 published sequences from France ( 14) and Russia ( 11).

RESULTS

We obtained 14 SNP sites among 72 individuals. Missense mutations C206T (Ser69Leu) and G253A (Val85Met) were observed in 16 and 8 Nigerian pigeons, respectively. The chi-squared test ( 0.05) for C206T, G253A, and A520G has the advantage of homozygous genotypes CC, GG, and AA, respectively. The association of C206T loci showed the advantage of CC genotype in ash-red, spread, and white pigeons, and TT in blue-bar, spread, and white feather pigeons. For G253A and A520G loci, GG and AA were dominant in all plumages except for genotype AA in G253A, which was prominent in ash-red, spread, and white plumages. The three SNPs were assigned to seven haplotypes. The median-joining network revealed 20 haplotypes, including 5 in Nigeria and 2 shared.

CONCLUSION

This study provides an insight into the association of variation and plumage diversity in Nigerian domestic pigeons. However, due to the limitation of the current data, we could not make further conclusions; this necessitates the need for more genomics studies on Nigerian pigeons.

摘要

目的

家鸽具有多种羽毛色素沉着。黑素皮质素1受体（MC1R）基因变异与颜色性状相关。非洲家鸽中MC1R与羽毛颜色之间的关联尚待研究。

材料与方法

在此，我们报告了来自尼日利亚的35只具有4种不同羽毛表型的家鸽的MC1R单核苷酸多态性（SNP）与羽毛之间的关系，以及来自法国（n = 14）和俄罗斯（n = 11）的37条已发表的MC1R序列。

结果

我们在72只个体中获得了14个SNP位点。在16只和8只尼日利亚鸽子中分别观察到错义突变C206T（Ser69Leu）和G253A（Val85Met）。C206T、G253A和A520G的卡方检验（P < 0.05）分别显示纯合基因型CC、GG和AA具有优势。C206T位点的关联显示，CC基因型在灰红、分布和白色鸽子中具有优势，而TT在蓝条、分布和白羽鸽子中具有优势。对于G253A和A520G位点，GG和AA在所有羽毛中占主导地位，除了G253A中的基因型AA在灰红、分布和白色羽毛中较为突出。这三个SNP被分配到七个单倍型。中介连接网络显示有20个单倍型，其中5个在尼日利亚，2个是共享的。