Altintas Mehmet Sait, Eyerci Nilnur, Karayigit Orhan, Demirtas Bekir, Gok Murat, Kiziltunc Emrullah
Istanbul Research and Training Hospital.
Kafkas University Faculty of Medicine.
Kardiologiia. 2022 Oct 30;62(10):49-55. doi: 10.18087/cardio.2022.10.n2155.
Aim In this study, we aimed to investigate the role of sCD163 / tumor necrosis factor-like weak apoptosis-inducing (TWEAK) ratio in cardiac remodeling in non-elderly patients diagnosed with first acute myocardial infarction (MI).Material and Methods Forty-four patients (age ranges: 40-64 years) diagnosed with first-time acute ST-elevation MI in the emergency department were evaluated with cardiac magnetic resonance (CMR) imaging. Adverse remodeling (AR) was defined the increases of left ventricular end-diastolic volume by ≥12 % by CMR at 6‑month post-MI TWEAK and sCD163 were measured at the first day (baseline), 2 weeks and 6 weeks post-MI.Results The average age of patients included in the study was 53.6±5.1 years. AR was detected in 18 patients at the 6 months post-MI. At the first day post-MI, median sCD163 concentration (116 069 vs 86 394 pg / mL, p=0.040) and median TWEAK concentration (759.4 vs 220.1 pg / mL, p<0.001) were higher in AR group compared to group without AR (the non-AR group), median sCD163 / TWEAK ratio (101.4 vs. 406.8; p<0.001) was lower. At the first day post-MI, concentrations of TWEAK and sCD163 showed a positive correlation in AR group and group without AR s. At 2 weeks post-MI, positive correlation continued in the non-AR group, but no significant correlation was found in the AR group. At the first day post-MI, sCD163 / TWEAK ratio was higher diagnostic performance compared to TWEAK and sCD163.Conclusion In the early phase post-MI, the relationship between sCD163 - TWEAK may have an important role in AR pathogenesis. A lower sCD163 / TWEAK ratio on the first day after MI was associated with an increase in left ventricular end-diastolic volume after 6 months of follow-up.
目的 在本研究中，我们旨在探讨可溶性CD163/肿瘤坏死因子样弱凋亡诱导因子（TWEAK）比值在首次诊断为急性心肌梗死（MI）的非老年患者心脏重塑中的作用。
材料与方法 对44例（年龄范围：40 - 64岁）在急诊科首次诊断为急性ST段抬高型MI的患者进行心脏磁共振（CMR）成像评估。不良重塑（AR）定义为MI后6个月时CMR显示左心室舒张末期容积增加≥12%。在MI后第1天（基线）、2周和6周测量TWEAK和sCD163。
结果 纳入研究的患者平均年龄为53.6±5.1岁。MI后6个月时在18例患者中检测到AR。MI后第1天，与无AR组（非AR组）相比，AR组的可溶性CD163浓度中位数（116 069对86 394 pg/mL，p = 0.040）和TWEAK浓度中位数（759.4对220.1 pg/mL，p < 0.001）更高，可溶性CD163/TWEAK比值中位数（101.4对406.8；p < 0.001）更低。MI后第1天，AR组和非AR组中TWEAK和可溶性CD163浓度呈正相关。MI后2周，非AR组中继续存在正相关，但AR组中未发现显著相关性。MI后第1天，可溶性CD163/TWEAK比值比TWEAK和可溶性CD163具有更高的诊断性能。
结论 在MI后早期，可溶性CD163 - TWEAK之间的关系可能在AR发病机制中起重要作用。MI后第1天较低的可溶性CD163/TWEAK比值与随访6个月后左心室舒张末期容积增加相关。
