Guangzhou University of Chinese Medicine, Guangzhou, China.
Guangdong Research Institute for Orthopedics and Traumatology of Chinese Medicine, NO.261, Longxi Road, Liwan District, Guangzhou, 510378, People's Republic of China.
J Orthop Surg Res. 2022 Nov 16;17(1):494. doi: 10.1186/s13018-022-03357-1.
The association between serum ferritin and bone mineral density (BMD) is still controversial. This study aims to investigate the association of serum ferritin level with BMD in US adults.
We conducted a cross-sectional study consisting of 8445 participants from National Health and Nutrition Examination Survey. Serum ferritin and lumbar spine BMD were used as independent variables and dependent variables, respectively. We evaluated the association between serum ferritin and lumbar spine BMD through a weighted multivariable linear regression model. Subgroup and interaction analysis was also performed in this study.
After adjusting for other confounding factors, serum ferritin was negatively correlated with lumbar spine BMD [β = - 0.090, 95% CI (- 0.135, - 0.045)]. Further subgroup analysis found that the strongest negative association mainly exists in females aged over 45 years [β = - 0.169, 95% CI (- 0.259, - 0.079)], and this association is not significant in other groups.
The results found that the association between serum ferritin and lumber spine BMD differed by gender and age. Increased level of serum ferritin may indicate a higher risk of osteoporosis or osteopenia in females aged over 45 years.
血清铁蛋白与骨密度（BMD）之间的关联仍存在争议。本研究旨在探讨美国成年人血清铁蛋白水平与 BMD 之间的关系。
我们进行了一项横断面研究，共有 8445 名来自国家健康和营养检查调查的参与者。血清铁蛋白和腰椎 BMD 分别作为自变量和因变量。我们通过加权多变量线性回归模型评估了血清铁蛋白与腰椎 BMD 之间的关系。本研究还进行了亚组和交互作用分析。
在调整了其他混杂因素后，血清铁蛋白与腰椎 BMD 呈负相关[β=-0.090，95%置信区间（-0.135，-0.045）]。进一步的亚组分析发现，最强的负相关主要存在于 45 岁以上的女性中[β=-0.169，95%置信区间（-0.259，-0.079）]，而在其他组中这种关联并不显著。
研究结果表明，血清铁蛋白与腰椎 BMD 之间的关联因性别和年龄而异。血清铁蛋白水平升高可能表明 45 岁以上女性骨质疏松症或骨量减少的风险更高。
