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用于基于化学动力学的联合治疗的纳米系统：策略与最新进展

Nanosystems for chemodynamic based combination therapy: Strategies and recent advances.

作者信息

Li Minghui, Zhang Wen, Xu Xiaopeng, Liu Guoying, Dong Mengfei, Sun Kaoxiang, Zhang Peng

机构信息

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China.

出版信息

Front Pharmacol. 2022 Oct 28;13:1065438. doi: 10.3389/fphar.2022.1065438. eCollection 2022.

DOI:10.3389/fphar.2022.1065438
PMID:36386143
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9651923/
Abstract

Chemodynamic therapy (CDT), a newly developed approach for cancer treatment, can convert hydrogen peroxide (HO) into toxic hydroxyl radicals (•OH) by using Fenton/Fenton-like reaction to kill tumor cells. However, due to the complexity of the intracellular environment of tumor cells, the therapeutic efficacy of CDT was severely restricted. Recently, combination therapy strategies have become popular approaches for tumor treatment, and there are numerous studies have demonstrated that the CDT-based combination strategies can significantly improve the anti-tumor efficiency of CDT. In this review, we outline some of the recent progress in cancer chemodynamic therapy from 2020, and discuss the progress in the design of nanosystems for CDT synergistic combination therapies.

摘要

化学动力疗法（CDT）是一种新开发的癌症治疗方法，它可以通过芬顿/类芬顿反应将过氧化氢（HO）转化为有毒的羟基自由基（•OH）来杀死肿瘤细胞。然而，由于肿瘤细胞内环境的复杂性，化学动力疗法的治疗效果受到严重限制。近年来，联合治疗策略已成为肿瘤治疗的常用方法，并且有大量研究表明，基于化学动力疗法的联合策略可以显著提高化学动力疗法的抗肿瘤效率。在这篇综述中，我们概述了2020年以来癌症化学动力疗法的一些最新进展，并讨论了用于化学动力疗法协同联合治疗的纳米系统设计方面的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fb1/9651923/9d703048d424/fphar-13-1065438-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fb1/9651923/9d703048d424/fphar-13-1065438-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fb1/9651923/9d703048d424/fphar-13-1065438-g001.jpg

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本文引用的文献

[1]
Highly Efficient GSH-Responsive "Off-On" NIR-II Fluorescent Fenton Nanocatalyst for Multimodal Imaging-Guided Photothermal/Chemodynamic Synergistic Cancer Therapy.

Anal Chem. 2022-7-26

[2]
Two-Dimensional MXene-Originated Nanosonosensitizer Generation for Augmented and Synergistic Sonodynamic Tumor Nanotherapy.

ACS Nano. 2022-6-28

[3]
Hotspots and Frontiers in Inflammatory Tumor Microenvironment Research: A Scientometric and Visualization Analysis.

Front Pharmacol. 2022-3-17

[4]
Nanoengineered Neutrophils as a Cellular Sonosensitizer for Visual Sonodynamic Therapy of Malignant Tumors.

Adv Mater. 2022-4

[5]
Construction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy.

Drug Deliv. 2022-12

[6]
A tumor microenvironment-responsive poly(amidoamine) dendrimer nanoplatform for hypoxia-responsive chemo/chemodynamic therapy.

J Nanobiotechnology. 2022-1-21

[7]
Engineering a pH/Glutathione-Responsive Tea Polyphenol Nanodevice as an Apoptosis/Ferroptosis-Inducing Agent.

ACS Appl Bio Mater. 2020-7-20

[8]
Charge reversal nano-systems for tumor therapy.

J Nanobiotechnology. 2022-1-10

[9]
Nanomedicine targets iron metabolism for cancer therapy.

Cancer Sci. 2022-3

[10]
One-Step Integration of Tumor Microenvironment-Responsive Calcium and Copper Peroxides Nanocomposite for Enhanced Chemodynamic/Ion-Interference Therapy.

ACS Nano. 2022-1-25

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