State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing, 210096, P. R. China.
Small. 2022 Feb;18(6):e2103868. doi: 10.1002/smll.202103868. Epub 2021 Nov 2.
Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton-like reaction to produce •OH in the tumor region, was first proposed by Bu, Shi, and co-workers in 2016. Recently, with the rapid development of Fenton and Fenton-like nanomaterials, CDT has attracted tremendous attention because of its unique advantages: 1) It is tumor-selective with low side effects; 2) the CDT process does not depend on external field stimulation; 3) it can modulate the hypoxic and immunosuppressive tumor microenvironment; 4) the treatment cost of CDT is low. In addition to the Fe-involved CDT strategies, the Fenton-like reaction-mediated CDT strategies have also been proposed, which are based on many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, and zinc. Moreover, CDT has been combined with other therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, and immunotherapy for achieving enhanced anticancer effects. Besides, there have also been studies that extend the application of CDT to the antibacterial field. This review introduces the latest advancements in the nanomaterials-involved CDT from 2018 to the present and proposes the current limitations as well as future research directions in the related field.
化学动力学疗法（CDT）是一种新型的癌症治疗策略，定义为利用芬顿或类芬顿反应在肿瘤区域产生·OH 的治疗方法，由 Bu、Shi 和同事于 2016 年首次提出。最近，随着 Fenton 和类 Fenton 纳米材料的快速发展，CDT 因其独特的优势吸引了人们的极大关注：1）它具有肿瘤选择性且副作用低；2）CDT 过程不依赖于外部场刺激；3）它可以调节缺氧和免疫抑制的肿瘤微环境；4）CDT 的治疗成本低。除了涉及 Fe 的 CDT 策略外，还提出了基于铜、锰、钴、钛、钒、钯、银、钼、钌、钨、铈和锌等许多其他金属元素的类 Fenton 反应介导的 CDT 策略。此外，CDT 已与化疗、放疗、光疗、声动力疗法和免疫疗法等其他疗法联合使用，以实现增强的抗癌效果。此外，还有研究将 CDT 的应用扩展到抗菌领域。本文介绍了 2018 年至今涉及纳米材料的 CDT 的最新进展，并提出了该领域当前的局限性和未来的研究方向。
