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肝母细胞瘤的外科策略和肝移植的最新进展。

Recent advances in surgical strategies and liver transplantation for hepatoblastoma.

机构信息

Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.

Department of Surgery, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.

出版信息

Cancer Med. 2023 Feb;12(4):3909-3918. doi: 10.1002/cam4.5300. Epub 2022 Nov 16.

Abstract

Hepatoblastoma (HB) is the most common malignant liver tumor in children. Although the development of treatment strategies with advances in chemotherapy has greatly improved the prognosis of HB, surgical resection and liver transplantation still play a vital role in the treatment of HB. In recent years, technological innovations have led to the development of new surgical approaches for HB. In this review, we describe the latest research on the surgical management of HB, including new imaging technologies, minimally invasive approaches, and the application of associating liver partition portal vein ligation for staged hepatectomy. We also discuss the current role of liver transplantation, use of ante-situm or ex-situ liver resection with auto-transplantation, and management of metastatic HB.

摘要

肝母细胞瘤 (HB) 是儿童中最常见的肝脏恶性肿瘤。尽管随着化疗的进展,治疗策略的发展极大地改善了 HB 的预后,但手术切除和肝移植仍然在 HB 的治疗中发挥着重要作用。近年来,技术创新导致了 HB 的新手术方法的发展。在这篇综述中,我们描述了 HB 手术治疗的最新研究进展,包括新的成像技术、微创方法以及联合肝脏离断和门静脉结扎的分阶段肝切除术的应用。我们还讨论了肝移植的当前作用、原位或异位肝切除联合自体移植的应用以及转移性 HB 的治疗管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3770/9972171/681a30a88894/CAM4-12-3909-g001.jpg

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