Alvarez-Jimenez Laura, Morales-Palomo Felix, Moreno-Cabañas Alfonso, Ortega Juan F, Mora-Rodriguez Ricardo
Exercise Physiology Lab at Toledo, University of Castilla-La Mancha, 45071 Toledo, Spain.
J Clin Endocrinol Metab. 2023 Apr 13;108(5):e139-e147. doi: 10.1210/clinem/dgac668.
Statins blunt cardiorespiratory fitness improvements after exercise training and may affect fat oxidation adaptations to training.
To determine if long-term statin use in dyslipidemic individuals restricts the improvements in fat oxidation typically observed after an intense exercise-training program.
A total of 106 metabolic syndrome individuals either chronically medicated with statins (ie, statin group; n = 46) or statin naive (ie, control group; n = 60) completed a 16-week supervised high-intensity interval training program. Maximal rates of oxygen consumption (V˙O2MAX), fat oxidation (FOMAX), and the shape of the workload-fat oxidation curve were assessed before and 48 hours after training in an overnight fasted state.
Starting from a similar value at baseline, both groups increased V˙O2MAX after training, but the increase was larger in the control than in the statin group (19.4% vs 12.6%; P = .013). Before training, FOMAX in the statin group was lower (0.19 ± 0.08 vs 0.23 ± 0.07 g·min-1; P = .023) and took place at a lower workload (33 ± 21 vs 37 ± 19 W; P = .015) than in the control group. After training, FOMAX improved similarly in both groups (0.06 ± 0.08; 95% CI, 0.03-0.08 g·min-1 and 0.05 ± 0.09; 95% CI, 0.03-0.07 g·min-1, for statin and control groups, respectively; (P < .001). Still, after training, FOMAX occurred at a 28% lower workload in the statin group (38 ± 26 vs 53 ± 32 W; P = .048). The V˙O2-workload slope decreased after training in both groups (both P < .001) along with reductions in the respiratory exchange ratio-workload slope. Fat oxidation increased at all workloads after training regardless of the use of statins.
Long-term statin treatment is associated with blunted exercise fat oxidation before exercise training. However, statin use does not attenuate the improvements in exercise fat oxidation (FOMAX) derived from intense aerobic exercise training. This finding should encourage statin users to exercise-train to benefit from increased fat oxidation once their fitness level improves.
他汀类药物会削弱运动训练后心肺功能的改善，并且可能影响脂肪氧化对训练的适应性。
确定血脂异常个体长期使用他汀类药物是否会限制在高强度运动训练计划后通常观察到的脂肪氧化改善情况。
总共106名患有代谢综合征的个体，其中一部分长期服用他汀类药物（即他汀类药物组；n = 46），另一部分未服用过他汀类药物（即对照组；n = 60），他们完成了一项为期16周的有监督的高强度间歇训练计划。在训练前以及训练后48小时处于空腹状态下，评估最大耗氧率（V˙O2MAX）、脂肪氧化（FOMAX）以及工作量-脂肪氧化曲线的形状。
两组在基线时的数值相似，训练后两组的V˙O2MAX均有所增加，但对照组的增加幅度大于他汀类药物组（19.4%对12.6%；P = .013）。训练前，他汀类药物组的FOMAX较低（0.19 ± 0.08对0.23 ± 0.07 g·min-1；P = .023），且发生在较低的工作量水平（33 ± 21对37 ± 19 W；P = .015）。训练后，两组的FOMAX均有相似程度的改善（他汀类药物组为0.06 ± 0.08；95%置信区间，0.03 - 0.08 g·min-1，对照组为0.05 ± 0.09；95%置信区间，0.03 - 0.07 g·min-1；P < .001）。然而，训练后，他汀类药物组的FOMAX在较低的工作量水平下出现（38 ± 26对53 ± 32 W；P = .048）。两组训练后V˙O2-工作量斜率均下降（均P < .001），同时呼吸交换率-工作量斜率也降低。无论是否使用他汀类药物，训练后所有工作量下的脂肪氧化均增加。
长期他汀类药物治疗与运动训练前运动脂肪氧化减弱有关。然而，使用他汀类药物并不会减弱高强度有氧运动训练带来的运动脂肪氧化（FOMAX）改善。这一发现应鼓励他汀类药物使用者进行运动训练，以便在体能水平提高后从增加的脂肪氧化中获益。
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