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高敏肌钙蛋白

High Sensitivity Troponins.

作者信息

Hempel Tyler Thomas, Wyatt Amy

机构信息

Department of Emergency Medicine, UPMC Harrisburg, 205 South Front Street, Brady 3 Suite 3A, Harrisburg, PA 17104, USA.

Department of Emergency Medicine, UPMC Harrisburg, 205 South Front Street, Brady 3 Suite 3A, Harrisburg, PA 17104, USA.

出版信息

Emerg Med Clin North Am. 2022 Nov;40(4):809-821. doi: 10.1016/j.emc.2022.07.002. Epub 2022 Oct 7.

Abstract

High-sensitivity cardiac troponin (hs-cTn) assays are highly specific to cardiac tissue and can detect small amounts of myocardial injury rapidly. Hs-cTn assays are the recommended cardiac biomarkers in the major US and European guidelines. In the appropriate clinical context, these assays allow clinicians to rapidly rule out a non-ST-elevation myocardial infarction and decrease 30-day major adverse cardiac events. This can have significant downstream impacts on the percentage of patients discharged from the emergency department (ED), ED lengths of stay, cardiac testing, and hospitalizations. There are many proposed diagnostic protocols and experts recommend institutions implement a single validated protocol.

摘要

高敏心肌肌钙蛋白(hs-cTn)检测对心脏组织具有高度特异性,能够快速检测出少量心肌损伤。在美国和欧洲的主要指南中,hs-cTn检测是推荐使用的心脏生物标志物。在适当的临床背景下,这些检测可使临床医生迅速排除非ST段抬高型心肌梗死,并减少30天主要不良心脏事件。这可能对从急诊科(ED)出院的患者比例、ED住院时间、心脏检查以及住院情况产生重大的下游影响。目前有许多提出的诊断方案,专家建议各机构实施单一经过验证的方案。

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