阿尔茨海默病的病理生理学。

Pathophysiology of Alzheimer's Disease.

机构信息

Psychiatry/Mental Health Service, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Building 401, Mail Code 116AE, Los Angeles, CA 90073, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, 757 Westwood Plaza #4, Los Angeles, CA 90095, USA.

Psychiatry/Mental Health Service, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Building 401, Mail Code 116AE, Los Angeles, CA 90073, USA.

出版信息

Psychiatr Clin North Am. 2022 Dec;45(4):663-676. doi: 10.1016/j.psc.2022.07.003. Epub 2022 Oct 14.

DOI:10.1016/j.psc.2022.07.003

PMID:36396271

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease leading to dementia worldwide. While neuritic plaques consisting of aggregated amyloid-beta proteins and neurofibrillary tangles of accumulated tau proteins represent the pathophysiologic hallmarks of AD, numerous processes likely interact with risk and protective factors and one's culture to produce the cognitive loss, neuropsychiatric symptoms, and functional impairments that characterize AD dementia. Recent biomarker and neuroimaging research has revealed how the pathophysiology of AD may lead to symptoms, and as the pathophysiology of AD gains clarity, more potential treatments are emerging that aim to modify the disease and relieve its burden.

摘要

阿尔茨海默病（AD）是全球范围内导致痴呆最常见的神经退行性疾病。虽然由聚集的淀粉样β蛋白组成的神经原纤维缠结和tau 蛋白积累的神经纤维缠结代表 AD 的病理生理特征，但许多过程可能与风险和保护因素以及一个人的文化相互作用，导致认知丧失、神经精神症状和功能障碍，这些都是 AD 痴呆的特征。最近的生物标志物和神经影像学研究揭示了 AD 的病理生理学如何导致症状，随着 AD 的病理生理学变得更加清晰，更多的潜在治疗方法正在出现，旨在改变疾病并减轻其负担。