老年期精神病性障碍：诊断、流行病学和治疗。

Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.

机构信息

Keenan Research Centre for Biomedical Science, Room 17044 cc wing, St. Michaels Hospital, #30 Bond St., Toronto, Ontario, M5B1W8, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; St. Michael's Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada.

Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

出版信息

Psychiatr Clin North Am. 2022 Dec;45(4):691-705. doi: 10.1016/j.psc.2022.07.001. Epub 2022 Oct 14.

DOI:10.1016/j.psc.2022.07.001

PMID:36396273

Abstract

This review covers the latest advances in our understanding of psychosis in the elderly population with respect to diagnosis, epidemiology, and treatment. Major topics of discussion include late life psychiatric disorders such as schizophrenia, schizoaffective disorder, and delusional disorder as well as dementia-related psychosis. Clinical differences between early-onset and late-onset disorders are reviewed in terms of prevalence, symptomatology, and approach to treatment. Newly revised research and clinical criteria for dementia-related psychosis are referenced. The evidence base for emerging therapies including citalopram and pimavanserin in relation to conventional therapies such as atypical antipsychotics are discussed..

摘要

这篇综述涵盖了我们在老年人精神病学方面的最新进展，包括诊断、流行病学和治疗。主要讨论的主题包括老年期精神障碍，如精神分裂症、分裂情感障碍和妄想障碍，以及与痴呆相关的精神障碍。从患病率、症状学和治疗方法等方面回顾了早发性和晚发性疾病之间的临床差异。引用了新修订的与痴呆相关的精神障碍的研究和临床标准。讨论了包括西酞普兰和匹莫范色林在内的新兴疗法以及包括非典型抗精神病药在内的传统疗法的证据基础。