Schmidbauer V U, Yildirim M S, Dovjak G O, Weber M, Diogo M C, Milos R-I, Giordano V, Prayer F, Stuempflen M, Goeral K, Buchmayer J, Klebermass-Schrehof K, Berger A, Prayer D, Kasprian G
From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., M.S.Y., G.O.D., M.W., R.-I.M., F.P., M.S., D.P., G.K.).
Department of Neuroradiology (M.C.D.), Hospital Garcia de Orta, Almada, Portugal.
AJNR Am J Neuroradiol. 2022 Dec;43(12):1817-1823. doi: 10.3174/ajnr.A7710. Epub 2022 Nov 17.
Multidynamic multiecho sequence-based imaging enables investigators to reconstruct multiple MR imaging contrasts on the basis of a single scan. This study investigated the feasibility of synthetic MRI-based WM signal suppression (syWMSS), a synthetic inversion recovery approach in which a short TI suppresses myelin-related signals, for the identification of early myelinating brainstem pathways.
Thirty-one cases of neonatal MR imaging, which included multidynamic multiecho data and conventionally acquired T1- and T2-weighted sequences, were analyzed. The multidynamic multiecho postprocessing software SyMRI was used to generate syWMSS data (TR/TE/TI = 3000/5/410 ms). Two raters discriminated early myelinating brainstem pathways (decussation of the superior cerebellar peduncle, medial lemniscus, central tegmental tract, and medial longitudinal fascicle [the latter 3 assessed at the level of the pons]) on syWMSS data and reference standard contrasts.
On the basis of syWMSS data, the decussation of the superior cerebellar peduncle (31/31); left/right medial lemniscus (31/31; 30/31); left/right central tegmental tract (19/31; 20/31); and left/right medial longitudinal fascicle (30/31) were reliably identified by both raters. On the basis of T1-weighted contrasts, the decussation of the superior cerebellar peduncle (14/31); left/right medial lemniscus (22/31; 16/31); left/right central tegmental tract (1/31); and left/right medial longitudinal fascicle (9/31; 8/31) were reliably identified by both raters. On the basis of T2-weighted contrasts, the decussation of the superior cerebellar peduncle (28/31); left/right medial lemniscus (16/31; 12/31); left/right central tegmental tract (23/31; 18/31); and left/right medial longitudinal fascicle (15/31; 14/31) were reliably identified by both raters.
syWMSS data provide a feasible imaging technique with which to study early myelinating brainstem pathways. MR imaging approaches that use myelin signal suppression contribute to a more sensitive assessment of myelination patterns at early stages of cerebral development.
基于多动态多回波序列的成像使研究人员能够基于单次扫描重建多个磁共振成像对比度。本研究调查了基于合成磁共振成像的白质信号抑制（syWMSS）的可行性，这是一种合成反转恢复方法，其中短TI可抑制与髓鞘相关的信号，用于识别早期髓鞘化的脑干通路。
分析了31例新生儿磁共振成像病例，包括多动态多回波数据以及常规采集的T1加权和T2加权序列。使用多动态多回波后处理软件SyMRI生成syWMSS数据（TR/TE/TI = 3000/5/410 ms）。两名评估者在syWMSS数据和参考标准对比度上辨别早期髓鞘化的脑干通路（上小脑脚交叉、内侧丘系、中央被盖束和内侧纵束[后三者在脑桥水平评估]）。
基于syWMSS数据，两名评估者均能可靠识别上小脑脚交叉（31/31）；左侧/右侧内侧丘系（31/31；30/31）；左侧/右侧中央被盖束（19/31；20/31）；以及左侧/右侧内侧纵束（30/31）。基于T1加权对比度，两名评估者均能可靠识别上小脑脚交叉（14/31）；左侧/右侧内侧丘系（22/31；16/31）；左侧/右侧中央被盖束（1/31）；以及左侧/右侧内侧纵束（9/31；8/31）。基于T2加权对比度，两名评估者均能可靠识别上小脑脚交叉（28/31）；左侧/右侧内侧丘系（16/31；12/31）；左侧/右侧中央被盖束（23/31；18/31）；以及左侧/右侧内侧纵束（15/31；14/31）。
syWMSS数据提供了一种可行的成像技术，用于研究早期髓鞘化的脑干通路。使用髓鞘信号抑制的磁共振成像方法有助于在脑发育早期阶段更敏感地评估髓鞘化模式。
