Zhonghua Wei Chang Wai Ke Za Zhi. 2022 Nov 25;25(11):933-946. doi: 10.3760/cma.j.cn441530-20221024-00429.
Gastric acid suppressants, such as proton pump inhibitors, are one of the most widey used drugs worldwide. There is a very high frequency of abuse of gastric acid suppressants, leading huge waste of medical resources. Moreover, numerous studies have showed that acid suppressants were associated with a variety of adverse events, such as fractures and intestinal infections. Increasing guidelines and consensuses have been made to guide the appropriate use of acid suppressants. Gastrointestinal surgery is one of the fields with the largest prescriptions of acid suppressants. Acid suppressants are widely used for preventing anastomotic bleeding after upper gastrointestinal surgery, treating gastrointestinal bleeding and etc. However, most of these prescriptions are off-label uses lacking adequate evidentiary basis. Thus far, there is no guideline specific for appropriate use of acid suppressants in digestive surgeries. Therefore, Chinese Society of Upper Gastrointestinal Surgeons (CSUGS) and Chinese Gastric Cancer Association (CGCA) developed this clinical practice guideline based on the best research evidence and clinical expertise. The aim is to guide the appropriate use of gastric acid suppressants in gastrointestinal surgery, which in turn, increase the benefits of patients.
胃酸抑制剂，如质子泵抑制剂，是全球使用最广泛的药物之一。胃酸抑制剂的滥用频率非常高，导致医疗资源的巨大浪费。此外，大量研究表明，酸抑制剂与多种不良事件有关，如骨折和肠道感染。越来越多的指南和共识已制定出来，以指导酸抑制剂的合理使用。胃肠外科是酸抑制剂处方量最大的领域之一。酸抑制剂广泛用于预防上消化道手术后的吻合口出血、治疗胃肠道出血等。然而，这些处方大多属于缺乏充分证据基础的超说明书用药。迄今为止，尚无针对消化外科手术中酸抑制剂合理使用的指南。因此，中国上消化道外科医师学会（CSUGS）和中国胃癌协会（CGCA）基于最佳研究证据和临床专业知识制定了本临床实践指南。目的是指导胃肠外科手术中胃酸抑制剂的合理使用，从而提高患者的获益。
