Department of Gynecology and Obstetrics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Department of Gynecology and Obstetrics, Medical Park Hospital, Samsun, Turkey.
Medicine (Baltimore). 2022 Nov 11;101(45):e31529. doi: 10.1097/MD.0000000000031529.
The diagnosis of endometriosis may delay for many years due to non-deterministic symptoms and avoiding surgical interventions. Kisspeptins are hormones that interact with endometrial tissue to limit invasions during placentation and various cancers and are suggested to be also associated with endometriosis. This study evaluated if serum kisspeptin levels are associated with the invasion depth in endometriosis. Forty patients between 18 and 45 years of age and admitted to a tertiary-care Obstetrics and Gynecology Department between 2020 and 2021 with a diagnosis of endometriosis, and 40 patients without endometrioma were included in the study. Demographic, obstetric, clinical, and biochemical characteristics were evaluated in patients with superficial (SE) and deep infiltrating (DIE) endometriosis and healthy controls. Twenty patients (50%) had SE, 14 (35%) had DIE, and 22 (55%) had endometrioma in the patient group. Fertility rates were higher among controls, but similar between patients with SE and DIE. CA125 levels were significantly higher in the DIE group. SE and DIE groups had similar kisspeptin values, significantly higher than controls. CA125 and kisspeptin levels were not correlated in study groups. Serum kisspeptin levels were significantly different between endometriosis patients and healthy controls. However, kisspeptin levels were unable to differentiate endometriosis severity. Our results suggest that kisspeptins might play a role in the pathogenesis of endometriosis, which needs further assessment in more comprehensive studies.
由于非确定性症状和避免手术干预，子宫内膜异位症的诊断可能会延迟多年。 kisspeptins 是一种与子宫内膜组织相互作用的激素，可限制胎盘形成和各种癌症期间的侵袭，并被认为与子宫内膜异位症也有关。本研究评估了血清 kisspeptin 水平是否与子宫内膜异位症的侵袭深度有关。 2020 年至 2021 年间，共有 40 名年龄在 18 至 45 岁之间的患者在三级保健妇产科就诊，被诊断为子宫内膜异位症，另有 40 名无子宫内膜瘤的患者被纳入研究。对浅表性（SE）和深部浸润性（DIE）子宫内膜异位症患者和健康对照组的人口统计学、产科、临床和生化特征进行了评估。 20 名患者（50%）患有 SE，14 名（35%）患有 DIE，患者组中有 22 名（55%）患有子宫内膜瘤。对照组的生育能力较高，但 SE 和 DIE 患者之间相似。 DIE 组的 CA125 水平明显更高。 SE 和 DIE 组的 kisspeptin 值相似，明显高于对照组。在研究组中，CA125 和 kisspeptin 水平没有相关性。子宫内膜异位症患者和健康对照组之间的血清 kisspeptin 水平存在显著差异。然而，kisspeptin 水平无法区分子宫内膜异位症的严重程度。我们的研究结果表明，kisspeptins 可能在子宫内膜异位症的发病机制中发挥作用，需要在更全面的研究中进一步评估。
