亲吻素调节生育能力：不孕症治疗中未来潜在的治疗方法。
Kisspeptins Regulating Fertility: Potential Future Therapeutic Approach in Infertility Treatment.
作者信息
Kotanidou Sonia, Nikolettos Nikos, Kritsotaki Nektaria, Tsikouras Panagiotis, Tiptiri-Kourpeti Angeliki, Nikolettos Konstantinos
机构信息
Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Genesis Athens-Thrace Medically Assisted Reproduction Unit, Apalos, 68100 Alexandroupolis, Greece.
出版信息
J Clin Med. 2025 May 8;14(10):3284. doi: 10.3390/jcm14103284.
Kisspeptins play a crucial role in the normal functioning of the reproductive axis in both humans and animals by stimulating the secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus. Recent studies have investigated the association of kisspeptins to infertility of diverse causes and the therapeutic potential of kisspeptins in infertility. Exogenous administration of kisspeptins appears to hold significant promise in restoring fertility, with ongoing studies in their application in ovarian stimulation protocols and as cryoprotectants during vitrification. This review provides a comprehensive analysis of the role of kisspeptins in reproductive physiology and their potential as therapeutic agents for infertility, highlighting their advantages over conventional treatments and their future prospects in clinical practice.
在人类和动物中， kisspeptins通过刺激下丘脑分泌促性腺激素释放激素（GnRH），对生殖轴的正常功能发挥着关键作用。最近的研究探讨了kisspeptins与各种原因导致的不孕症之间的关联，以及kisspeptins在不孕症治疗中的潜力。外源性给予kisspeptins在恢复生育能力方面似乎具有巨大潜力，目前正在研究其在卵巢刺激方案中的应用以及作为玻璃化冷冻过程中的冷冻保护剂。本综述全面分析了kisspeptins在生殖生理学中的作用及其作为不孕症治疗药物的潜力，强调了它们相对于传统治疗方法的优势以及在临床实践中的未来前景。
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