Department of Otorhinolaryngology, Izmir Katip Celebi University Medical Faculty, Izmir, Turkey.
Department of Otorhinolaryngology, Biruni University Medical Faculty, Istanbul, Turkey.
Acta Otolaryngol. 2022 Sep-Dec;142(9-12):731-737. doi: 10.1080/00016489.2022.2142953. Epub 2022 Nov 17.
Determining a predictable duration to restenosis very essential for reducing mortality and morbidity for tracheal stenosis surgery.
The aim of this study was to determine the critical periods for secondary restenosis risk for operated patients with post-intubation tracheal stenosis (PITS) during the initial healing period.
A total of 61 patients with a diagnosis of surgically treated PITS were included in the study. Treatment groups were carbon dioxide (CO) laser and tracheal resection with primary anastomosis (TRPA). Duration to restenosis was compared with Kaplan-Meier curves between study groups.
Restenosis developed in 11 (18.0%) patients and was diagnosed after a mean of 39.3 ± 38.5 (range, 22 to 155) days. Gender or Cotton-Myer grade of the PITS was not found to be risk factors for the development of stenosis. Restenosis rate was 33.3% in CO laser group and 10% in the TRPA group ( = .036). Duration to restenosis was detected at a median of 28 days in patients treated with CO laser, and a median of 30 days in patients treated with TRPA ( = .024).
The most critical period for the development of restenosis after PITS treatment is the third and fourth weeks, especially in patients treated with CO laser.
确定再狭窄的可预测时间对于降低气管狭窄手术的死亡率和发病率非常重要。
本研究旨在确定接受气管切开术后气管狭窄（PITS）手术治疗的患者在初始愈合期内发生继发性再狭窄风险的关键时期。
共纳入 61 例经手术治疗的 PITS 患者。治疗组为二氧化碳（CO）激光和气管切除术伴一期吻合术（TRPA）。通过 Kaplan-Meier 曲线比较研究组之间的再狭窄时间。
11 例（18.0%）患者出现再狭窄，平均诊断时间为 39.3±38.5（范围，22-155）天。PITS 的性别或 Cotton-Myer 分级不是狭窄发展的危险因素。CO 激光组的再狭窄发生率为 33.3%，TRPA 组为 10%（ = .036）。CO 激光治疗患者的再狭窄时间中位数为 28 天，TRPA 治疗患者的再狭窄时间中位数为 30 天（ = .024）。
PITS 治疗后再狭窄发展的最关键时期是第三和第四周，尤其是接受 CO 激光治疗的患者。
