Value of blood gas analysis and immunological indicators in early diagnosis and treatment monitoring of children with severe pneumonia and sepsis.

OBJECTIVE

This study was designed to investigate the clinical value of blood gas analysis and related immunological indicators in the early diagnosis and treatment monitoring of children with severe pneumonia and sepsis.

METHODS

A retrospective study was conducted on children with pneumonia and sepsis and healthy children undergoing physical examination in the First People's Hospital of Fuyang Hangzhou from January 2020 to December 2020. A total of 31 children with pneumonia and sepsis (observation group) and 31 healthy children (control group) were included. The levels of partial pressure of carbon dioxide (PaCO), partial pressure of oxygen (PaO), pH, immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin G (IgG), complement 3 (C3) and complement 4 (C4) were compared between the two groups. The changes of blood gas analysis indices and immune indices in the observation group before treatment (T0), as well as after 1 month (T1), 2 months (T2) and 3 months (T3) of treatment were dynamically analyzed.

RESULTS

Compared with the control group, the level of PaCO was significantly increased, and the levels of PaO, pH, IgA, IgM, IgG, C3 and C4 were significantly decreased in the observation group, showing statistically significant differences ( < 0.05). With the progress of treatment, the levels of PaO, PH, IgA, IgM, IgG, C3 and C4 showed a slowly increasing trend, while PaCO gradually decreased, and the differences between T3 and T0 were statistically significant ( < 0.05). ROC curve analysis showed that PaCO, PaO, PH, IgA, IgM, IgG, C3 and C4 had good diagnostic value for severe pneumonia combined with sepsis ( < 0.05).

CONCLUSION

Blood gas analysis and immune indices exhibited high precision in early diagnosis and treatment monitoring of children with severe pneumonia and sepsis.