Division of Pediatric Critical Care Medicine, Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, FA.2.112, 4800 Sand Point Way NE, Seattle, WA 98105, USA.
Division of Pediatric Infectious Diseases, Children's Mercy, Kansas City, University of Missouri-Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO 64108, USA.
Infect Dis Clin North Am. 2018 Mar;32(1):119-128. doi: 10.1016/j.idc.2017.10.005. Epub 2017 Dec 9.
Haemophilus influenzae remains a common cause of illness in children throughout the world. Before the introduction of vaccination, H influenzae type b (Hib) disease was the leading cause of bacterial meningitis in young children and a frequent cause of pneumonia, epiglottitis, and septic arthritis. Clinicians should remain diligent in counseling parents on the dangers of Hib and provide vaccination starting at 2 months of age. The epidemiology of invasive H influenzae disease is shifting. It is imperative that clinicians recognize the changing epidemiology and antibiotic resistance patterns for H influenzae to optimize care in hospital and ambulatory settings.
流感嗜血杆菌仍然是全世界儿童患病的常见原因。在疫苗接种引入之前,乙型流感嗜血杆菌(Hib)疾病是导致幼儿细菌性脑膜炎的主要原因,也是肺炎、会厌炎和化脓性关节炎的常见原因。临床医生应继续向家长宣传 Hib 的危害,并从 2 个月大开始接种疫苗。侵袭性流感嗜血杆菌病的流行病学正在发生变化。临床医生必须认识到流感嗜血杆菌的流行病学和抗生素耐药模式的变化,以优化医院和门诊环境中的护理。