Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada.
J Cutan Pathol. 2023 Mar;50(3):275-278. doi: 10.1111/cup.14361. Epub 2022 Dec 2.
Oral melanocytic neoplasms pose a diagnostic challenge to pathologists owing to their rarity relative to those in the skin. The utility of PRAME in distinguishing nevi from melanomas has been established in the skin, but limited information exists regarding its usefulness in the oral cavity.
Thirty-five previously diagnosed pigmented oral lesions were retrospectively evaluated with PRAME. The lesions consisted of 16 oral nevi, 10 melanomas, and 10 melanotic macules.
Strong and diffuse nuclear PRAME staining was observed in all but one of the oral melanomas, which showed no staining. No nuclear PRAME staining was observed in any of the oral nevi or melanotic macules.
PRAME is a useful tool in the evaluation of oral melanocytic neoplasms. Our data indicate that PRAME is a highly specific but incompletely sensitive marker of oral melanoma. Larger studies could further illuminate the diagnostic value of PRAME in oral lesions.
口腔黑色素细胞肿瘤相对皮肤肿瘤较为罕见，这给病理学家的诊断带来了挑战。PRAME 在区分痣和黑色素瘤方面在皮肤中的应用已经得到了证实，但关于其在口腔中的应用价值的信息有限。
回顾性分析了 35 例已诊断的色素性口腔病变的 PRAME 表达情况。病变包括 16 例口腔痣、10 例黑色素瘤和 10 例色素斑。
除了一例黑色素瘤未染色外，所有口腔黑色素瘤均表现出强烈且弥漫的核 PRAME 染色，而口腔痣或色素斑均未见核 PRAME 染色。
PRAME 是评估口腔黑色素细胞肿瘤的有用工具。我们的数据表明 PRAME 是口腔黑色素瘤高度特异但不完全敏感的标志物。更大规模的研究可以进一步阐明 PRAME 在口腔病变中的诊断价值。
