镰状细胞病的心肺并发症。
The Cardiopulmonary Complications of Sickle Cell Disease.
机构信息
Department of Medicine, Indiana School of Medicine, Indianapolis, IN, USA; Indiana University, 950 W. Walnut Street R2 Building, Room 466, Indianapolis, IN 46202, USA.
Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Room C400, Walther Hall, R3 980 W. Walnut Street, Indianapolis, IN 46202, USA.
出版信息
Hematol Oncol Clin North Am. 2022 Dec;36(6):1217-1237. doi: 10.1016/j.hoc.2022.07.014.
Sickle cell disease (SCD) is a genetic hemoglobinopathy associated with extensive morbidity and early mortality. While there have been recent improvements in available disease-modifying therapies for SCD, cardiopulmonary complications remain a major risk factor for death in this population. We provide an overview of current knowledge regarding several of the major acute and chronic cardiopulmonary complications in SCD, including: acute chest syndrome, airway disease, lung function abnormalities, nocturnal hypoxemia and sleep disordered breathing, pulmonary vascular disease, and sickle cell cardiomyopathy.
镰状细胞病（SCD）是一种遗传性血红蛋白病，与广泛的发病率和早期死亡率有关。尽管近年来 SCD 的可用疾病修饰疗法有所改进，但心肺并发症仍然是该人群死亡的主要危险因素。我们提供了关于 SCD 中几种主要的急性和慢性心肺并发症的现有知识概述，包括：急性胸部综合征、气道疾病、肺功能异常、夜间低氧血症和睡眠呼吸障碍、肺血管疾病和镰状细胞心肌病。
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