镰状细胞病与肾脏：滤过功能失常

Sickle Cell Disease and the Kidney: Filters Gone Awry.

作者信息

Lebensburger Jeffrey D, Derebail Vimal K

机构信息

Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Alabama at Birmingham, 1600 7th Avenue South, Lowder 512, Birmingham, AL 35233, USA.

Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, UNC Kidney Center, 7024 Burnett-Womack, CB 7155, Chapel Hill, NC 27599, USA.

出版信息

Hematol Oncol Clin North Am. 2022 Dec;36(6):1239-1254. doi: 10.1016/j.hoc.2022.08.009.

DOI:10.1016/j.hoc.2022.08.009

PMID:36400541

Abstract

Throughout the lifespan, the kidney of a person with sickle cell disease is at increased risk of injury to the glomeruli, tubules, and renal vasculature. This injury manifests as urine concentrating defects, enuresis, albuminuria, acute kidney injury, chronic kidney disease, and end-stage kidney disease. The outcomes for patients who progress to end-stage kidney disease are poor and access to organ transplantation is limited. Therefore, identifying risk factors for progression, intervening with renoprotective agents early in life, and improving access to care are vital for sickle cell patients.

摘要

在整个生命周期中，镰状细胞病患者的肾脏发生肾小球、肾小管和肾血管损伤的风险增加。这种损伤表现为尿液浓缩功能缺陷、遗尿、蛋白尿、急性肾损伤、慢性肾病和终末期肾病。进展至终末期肾病的患者预后较差，器官移植的机会有限。因此，识别疾病进展的风险因素、在生命早期使用肾脏保护药物进行干预以及改善医疗服务的可及性对镰状细胞病患者至关重要。