Memorial Ankara Hospital, Department of Orthopaedics and Traumatology, Ankara, Turkey.
Hitit University, Faculty of Medicine, Department of Orthopaedics and Traumatology, Çorum, Turkey.
Medicine (Baltimore). 2022 Nov 18;101(46):e31406. doi: 10.1097/MD.0000000000031406.
Advances in the biology of Ewing sarcoma, which continues to be an important cause of mortality, have caused an increase in information in the literature related to the underlying molecular base of the disease and discussions of new treatment approaches. In this study, we aimed to comprehensively analyze the published scientific articles on Ewing sarcoma. The Web of Science database was used to obtain and statistically analysis articles on Ewing sarcoma that were published between 1980 and 2021. Maps of network visualization were used to reveal trending topics, global collaborations, and the most effective studies. Correlation analysis was performed using Spearman's correlation coefficient. A total of 3236 articles were analyzed. The first 3 countries that contributed the most to the literature and cooperated most intensively were USA (1194, 36.8%), Germany (293, 9%), Italy (254, 7.8%). Pediatric Blood & Cancer (n = 122), Cancer (87), Journal of Pediatric Hematology Oncology (71) were among the top 3 journals with the most articles. The most active author was Piero Picci (n = 94). High-income countries have a great effect on the literature on this subject. The most studied trend topics in recent years were pediatric oncology, EWS RNA Binding Protein 1 (EWSR1), EWSR1-FL1, epigenetics, bioinformatics, microRNA, gene expression, metastasis, migration, biomarker, immunotherapy, survival, outcomes, surveillance epidemiology and end results (SEER), nomogram, temozolomide, irinotecan, and drug resistance. Genetic studies, metastasis, immunotherapy, life analyses/nomogram based on new data obtained from SEER, and chemotherapy with irinotecan and temozolomide combination, were seen to be the topics researched in recent years.
尤文肉瘤生物学的进展，仍然是导致死亡率的重要原因，这导致了与疾病潜在分子基础相关的文献信息的增加，以及对新治疗方法的讨论。在这项研究中，我们旨在全面分析已发表的尤文肉瘤科学文献。我们使用 Web of Science 数据库获取并对 1980 年至 2021 年发表的尤文肉瘤相关文章进行了统计分析。网络可视化图谱用于揭示热门话题、全球合作和最有效的研究。使用 Spearman 相关系数进行相关性分析。共分析了 3236 篇文章。对文献贡献最多、合作最密切的前 3 个国家是美国（1194，36.8%）、德国（293，9%）和意大利（254，7.8%）。发表文章最多的前 3 种期刊是 Pediatric Blood & Cancer（n = 122）、Cancer（87）和 Journal of Pediatric Hematology Oncology（71）。最活跃的作者是 Piero Picci（n = 94）。高收入国家对该主题的文献有很大的影响。近年来研究最多的趋势话题是儿科肿瘤学、EWS RNA 结合蛋白 1（EWSR1）、EWS-FL1、表观遗传学、生物信息学、microRNA、基因表达、转移、迁移、生物标志物、免疫疗法、生存、结果、监测流行病学和最终结果（SEER）、列线图、替莫唑胺、伊立替康和耐药性。遗传研究、转移、免疫疗法、基于从 SEER 获得的新数据的生命分析/列线图，以及伊立替康和替莫唑胺联合化疗，被认为是近年来研究的课题。
