Department of Maxillofacial Biomedical Engineering, College of Dentistry, Kyung Hee University, Seoul, 02447, Republic of Korea.
Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.
Commun Biol. 2022 Nov 19;5(1):1270. doi: 10.1038/s42003-022-04232-9.
Here we show that intradermal injection of keratin promotes hair growth in mice, which results from extracellular interaction of keratin with hair forming cells. Extracellular application of keratin induces condensation of dermal papilla cells and the generation of a P-cadherin-expressing cell population (hair germ) from outer root sheath cells via keratin-mediated microenvironmental changes. Exogenous keratin-mediated hair growth is reflected by the finding that keratin exposure from transforming growth factor beta 2 (TGFβ2)-induced apoptotic outer root sheath cells appears to be critical for dermal papilla cell condensation and P-cadherin-expressing hair germ formation. Immunodepletion or downregulation of keratin released from or expressed in TGFβ2-induced apoptotic outer root sheath cells negatively influences dermal papilla cell condensation and hair germ formation. Our pilot study provides an evidence on initiating hair regeneration and insight into the biological function of keratin exposed from apoptotic epithelial cells in tissue regeneration and development.
在这里，我们展示了角蛋白的皮内注射可促进小鼠的毛发生长，这是由于角蛋白与毛发生成细胞的细胞外相互作用所致。角蛋白的细胞外应用诱导真皮乳头细胞的凝聚，并通过角蛋白介导的微环境变化从外根鞘细胞产生表达 P-钙黏蛋白的细胞群体（毛胚芽）。角蛋白介导的毛发生长的外在表现是，转化生长因子β 2（TGFβ2）诱导的凋亡外根鞘细胞中角蛋白的暴露似乎对角质形成细胞的凝聚和表达 P-钙黏蛋白的毛胚芽形成至关重要。免疫耗竭或下调 TGFβ2 诱导的凋亡外根鞘细胞中释放或表达的角蛋白会对真皮乳头细胞的凝聚和毛胚芽的形成产生负面影响。我们的初步研究为启动毛发生成提供了证据，并深入了解了凋亡上皮细胞中暴露的角蛋白在组织再生和发育中的生物学功能。
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