School of Medical Laboratory, Weifang Medical University, Weifang, China.
Institutional Key Laboratory of clinical laboratory Diagnostics, 12th 5-Year project of Shandong Province, Weifang Medical University, Weifang, China.
Chem Biol Drug Des. 2023 Mar;101(3):794-808. doi: 10.1111/cbdd.14182. Epub 2022 Nov 29.
Purinergic ligand-gated ion channel 7 receptor (P2X7 receptor) is an adenosine triphosphate (ATP)-gated ion channel that is widely distributed on the surfaces of immune cells and tissues such as those in the liver, kidney, lung, intestine, and nervous system. Hepatocellular carcinoma (HCC) is one of the most common malignancies with increasing incidence and mortality. Although many treatments for liver cancer have been studied, the prognosis for liver cancer is still very poor. Therefore, new liver cancer treatments are urgently needed. P2X7 receptor activation can secrete proinflammatory factors through the P2X7 receptor-NLRP3 signaling pathway, thereby affecting the progression of liver injury. The P2X7 receptor may be a target for growth inhibition of HCC cells and may affect the invasion and migration of HCC cells through the PI3K/AKT and AMPK signaling pathways. In recent years, P2X7 receptor antagonists or inhibitors have attracted widespread attention as therapeutic targets for hepatocellular carcinoma and liver injury. Therefore, this review covers the basic concepts of the P2X7 receptor and role of the P2X7 receptor in liver cancer and liver injury, providing new potential therapeutic targets for hepatocellular carcinoma and liver injury.
嘌呤能配体门控离子通道 7 型受体（P2X7 受体）是一种三磷酸腺苷（ATP）门控离子通道，广泛分布于免疫细胞和组织表面，如肝脏、肾脏、肺、肠道和神经系统。肝细胞癌（HCC）是最常见的恶性肿瘤之一，发病率和死亡率呈上升趋势。尽管已经研究了许多治疗肝癌的方法，但肝癌的预后仍然很差。因此，迫切需要新的肝癌治疗方法。P2X7 受体的激活可以通过 P2X7 受体-NLRP3 信号通路分泌促炎因子，从而影响肝损伤的进展。P2X7 受体可能是 HCC 细胞生长抑制的靶点，并可能通过 PI3K/AKT 和 AMPK 信号通路影响 HCC 细胞的侵袭和迁移。近年来，P2X7 受体拮抗剂或抑制剂作为肝癌和肝损伤的治疗靶点引起了广泛关注。因此，本综述涵盖了 P2X7 受体的基本概念以及 P2X7 受体在肝癌和肝损伤中的作用，为肝癌和肝损伤提供了新的潜在治疗靶点。
