School of Medical Laboratory, Weifang Medical University.
Institutional Key Laboratory of Clinical Laboratory Diagnostics, 12th 5-Year project of Shandong Province, Weifang Medical University, Weifang, Shandong, China.
Eur J Cancer Prev. 2024 May 1;33(3):271-281. doi: 10.1097/CEJ.0000000000000851. Epub 2023 Nov 6.
The incidence of digestive malignancies has increased in recent years, including colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pancreatic cancer. Advanced stages of these cancers are prone to metastasis, which seriously reduce the standard of living of patients and lead to decline in the survival rate of patients. So far there are no good specific drugs to stop this phenomenon. It is very important and urgent to find new biomarkers and therapeutic targets. Purinergic ligand-gated ion channel 7 receptor (P2X7R) is ATP-gated and nonselective ion channel receptor involved in many inflammatory processes and cancer progression. P2X7R is present in many cancer cells and promotes or inhibits cancer development through signal transduction. Studies have presented that P2X7R plays a role in the proliferation and migration of digestive system cancers, such as CRC, HCC and pancreatic cancer. Therefore, P2X7R may serve as a biomarker or therapeutic target for digestive system cancers. This paper describes the structure and function of P2X7R, and mainly reviews the research progress on the role of P2X7R in CRC, HCC and pancreatic cancer.
近年来，消化系统恶性肿瘤的发病率有所增加，包括结直肠癌（CRC）、肝细胞癌（HCC）和胰腺癌。这些癌症的晚期易发生转移，严重降低了患者的生活质量，并导致患者的生存率下降。到目前为止，还没有很好的特效药物来阻止这种现象。寻找新的生物标志物和治疗靶点非常重要和紧迫。嘌呤能配体门控离子通道 7 型受体（P2X7R）是一种 ATP 门控的非选择性离子通道受体，参与多种炎症过程和癌症进展。P2X7R 存在于许多癌细胞中，并通过信号转导促进或抑制癌症的发展。研究表明，P2X7R 在结直肠癌、肝细胞癌和胰腺癌等消化系统癌症的增殖和迁移中发挥作用。因此，P2X7R 可能作为消化系统癌症的生物标志物或治疗靶点。本文描述了 P2X7R 的结构和功能，并主要综述了 P2X7R 在结直肠癌、肝细胞癌和胰腺癌中的作用研究进展。
