Department of Dermatology, Hangzhou Third People's Hospital, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Dermatology, Hangzhou Third People's Hospital, Affiliated Hangzhou Dermatology Hospital, Zhejiang University School of Medicine, Hangzhou, China.
J Cosmet Laser Ther. 2022 Nov 17;24(6-8):73-79. doi: 10.1080/14764172.2022.2148186. Epub 2022 Nov 20.
Laser-assisted drug delivery (LADD) is a new treatment for delivering drugs within the skin. This meta-analysis investigates the effectiveness and safety of the laser-assisted delivery of tranexamic acid (TXA) to treat melasma. A literature review was conducted by searching publication platforms to search for randomized controlled trials (RCTs) that compared laser-assisted delivery of TXA with laser-alone or topical TXA-alone treatment. The Embase, Web of Science, PubMed, Google Scholar, and Cochrane Library databases were searched, and Melasma Area Severity Index (MASI)/modified MASI (mMASI) scores used as the clinical improvement outcomes. All statistical analyses were performed using the RevMan software (Review Manager, V.5.3). The standardized mean differences and 95% confidence intervals were used to assess the results. Five RCTs were included in this meta-analysis. These studies used ablative fractional photothermolysis and nonablative dermal remodeling laser modalities. The results showed that both laser modalities combined with TXA significantly decreased the MASI/mMASI scores (P = .0003). Furthermore, no serious adverse events were observed, except mild erythema and burning pain. The meta-analysis found that the laser-assisted delivery of TXA is a new effective and safe treatment option for melasma treatment.
激光辅助药物递送 (LADD) 是一种将药物递送至皮肤内的新疗法。本荟萃分析旨在研究激光辅助氨甲环酸 (TXA) 递送治疗黄褐斑的有效性和安全性。通过在 Embase、Web of Science、PubMed、Google Scholar 和 Cochrane Library 数据库中检索，检索了比较激光辅助 TXA 递送与激光单独或局部 TXA 单独治疗的随机对照试验 (RCT)。采用 RevMan 软件 (Review Manager，V.5.3) 进行所有统计分析。采用标准化均数差及 95%置信区间评估结果。本荟萃分析纳入了 5 项 RCT。这些研究采用了剥脱性和非剥脱性皮肤重塑激光模式。结果表明，两种激光模式联合 TXA 均能显著降低 MASI/mMASI 评分（P=0.0003）。此外，除轻度红斑和灼热痛外，未观察到严重不良事件。荟萃分析发现，激光辅助 TXA 递送是治疗黄褐斑的一种新的有效且安全的治疗选择。
